Zhilong Huoxue Tongyu capsule inhibits hypertensive myocardial fibrosis via balancing TGF-β1/Smad3/Erbb4-IR/miR-29b pathway

Zhilong Huoxue Tongyu capsule inhibits hypertensive myocardial fibrosis via balancing TGF-β1/Smad3/Erbb4-IR/miR-29b pathway

Abstract Zhilong Huoxue Tongyu capsule (ZL) is wildly used as a Chinese patent medicine for the treatment of cardiovascular diseases. Clinical studies have found that it can significantly improve hypertension and heart failure. However, its precise molecular mechanisms remain incompletely understood...

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Bibliographic Details
Main Authors: Qiuyu Liu, Dingshan Zhang, Raoqiong Wang, Shihan Sun, Yuanyuan Li, Zhenxun Wan, Yumei Qian, Xinrui Yang, Gang Luo, Mingtai Chen, Mengnan Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Zhilong Huoxue Tongyu capsule
Hypertensive
Heart failure
Myocardial fibrosis
TGF-β1/Smad3/Erbb4-IR/miR-29b pathway
Online Access:https://doi.org/10.1038/s41598-025-10631-9
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