Recent Advances in Chitosan-Based Metal Nanocomposites for Wound Healing Applications
Chitosan (CS) has been extensively studied as a natural polymer, in the field of wound repair, due to its useful properties, which include a lack of toxicity and stimulation, excellent biological affinity, degradability, and promotion of collagen deposition. However, inferior mechanical strength and...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2020/3827912 |
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| _version_ | 1832566292599537664 |
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| author | Kai Wang Su Pan Zhiping Qi Peng Xia Haotian Xu Weijian Kong Hongru Li Pan Xue Xiaoyu Yang Chuan Fu |
| author_facet | Kai Wang Su Pan Zhiping Qi Peng Xia Haotian Xu Weijian Kong Hongru Li Pan Xue Xiaoyu Yang Chuan Fu |
| author_sort | Kai Wang |
| collection | DOAJ |
| description | Chitosan (CS) has been extensively studied as a natural polymer, in the field of wound repair, due to its useful properties, which include a lack of toxicity and stimulation, excellent biological affinity, degradability, and promotion of collagen deposition. However, inferior mechanical strength and moderate antibacterial properties are the drawbacks restricting its further clinical application. Many researchers have adopted the use of nanotechnology, in particular metallic nanoparticles (MNPs), in order to improve the mechanical strength and specific antibacterial properties of chitosan composites, with promising results. Furthermore, chitosan naturally functions as a reducing agent for MNPs, which can also reduce cytotoxicity. Thus, CS, in combination with MNPs, exhibits antibacterial activity, excellent mechanical strength, and anti-inflammatory properties, and it has great potential to accelerate the process of wound healing. This review discusses the current use of CS and MNPs in wound healing and emphasises the synergy and the advantages for various applications in wound healing. |
| format | Article |
| id | doaj-art-a63fa4cc74d848b6a4ef903591f3bc80 |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-a63fa4cc74d848b6a4ef903591f3bc802025-02-03T01:04:38ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422020-01-01202010.1155/2020/38279123827912Recent Advances in Chitosan-Based Metal Nanocomposites for Wound Healing ApplicationsKai Wang0Su Pan1Zhiping Qi2Peng Xia3Haotian Xu4Weijian Kong5Hongru Li6Pan Xue7Xiaoyu Yang8Chuan Fu9The Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaThe Second Hospital of Jilin University, Changchun, Jilin 130041, ChinaChitosan (CS) has been extensively studied as a natural polymer, in the field of wound repair, due to its useful properties, which include a lack of toxicity and stimulation, excellent biological affinity, degradability, and promotion of collagen deposition. However, inferior mechanical strength and moderate antibacterial properties are the drawbacks restricting its further clinical application. Many researchers have adopted the use of nanotechnology, in particular metallic nanoparticles (MNPs), in order to improve the mechanical strength and specific antibacterial properties of chitosan composites, with promising results. Furthermore, chitosan naturally functions as a reducing agent for MNPs, which can also reduce cytotoxicity. Thus, CS, in combination with MNPs, exhibits antibacterial activity, excellent mechanical strength, and anti-inflammatory properties, and it has great potential to accelerate the process of wound healing. This review discusses the current use of CS and MNPs in wound healing and emphasises the synergy and the advantages for various applications in wound healing.http://dx.doi.org/10.1155/2020/3827912 |
| spellingShingle | Kai Wang Su Pan Zhiping Qi Peng Xia Haotian Xu Weijian Kong Hongru Li Pan Xue Xiaoyu Yang Chuan Fu Recent Advances in Chitosan-Based Metal Nanocomposites for Wound Healing Applications Advances in Materials Science and Engineering |
| title | Recent Advances in Chitosan-Based Metal Nanocomposites for Wound Healing Applications |
| title_full | Recent Advances in Chitosan-Based Metal Nanocomposites for Wound Healing Applications |
| title_fullStr | Recent Advances in Chitosan-Based Metal Nanocomposites for Wound Healing Applications |
| title_full_unstemmed | Recent Advances in Chitosan-Based Metal Nanocomposites for Wound Healing Applications |
| title_short | Recent Advances in Chitosan-Based Metal Nanocomposites for Wound Healing Applications |
| title_sort | recent advances in chitosan based metal nanocomposites for wound healing applications |
| url | http://dx.doi.org/10.1155/2020/3827912 |
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