Complications of stent placement in patients with esophageal cancer: A systematic review and network meta-analysis.
<h4>Background</h4>Palliative treatments and stents are necessary for relieving dysphagia in patients with esophageal cancer. The aim of this study was to simultaneously compare available treatments in terms of complications.<h4>Methods</h4>Web of Science, Medline, Scopus, Co...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0184784 |
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| author | Amin Doosti-Irani Mohammad Ali Mansournia Abbas Rahimi-Foroushani Peiman Haddad Kourosh Holakouie-Naieni |
| author_facet | Amin Doosti-Irani Mohammad Ali Mansournia Abbas Rahimi-Foroushani Peiman Haddad Kourosh Holakouie-Naieni |
| author_sort | Amin Doosti-Irani |
| collection | DOAJ |
| description | <h4>Background</h4>Palliative treatments and stents are necessary for relieving dysphagia in patients with esophageal cancer. The aim of this study was to simultaneously compare available treatments in terms of complications.<h4>Methods</h4>Web of Science, Medline, Scopus, Cochrane Library and Embase were searched. Statistical heterogeneity was assessed using the Chi2 test and was quantified by I2. The results of this study were summarized in terms of Risk Ratio (RR). The random effects model was used to report the results. The rank probability for each treatment was calculated using the p-score.<h4>Results</h4>Out of 17855 references, 24 RCTs reported complications including treatment related death (TRD), bleeding, stent migration, aspiration, severe pain and fistula formation. In the ranking of treatments, thermal ablative therapy (p-score = 0.82), covered Evolution® stent (p-score = 0.70), brachytherapy (p-score = 0.72) and antireflux stent (p-score = 0.74) were better treatments in the network of TRD. Thermal ablative therapy (p-score = 0.86), the conventional stent (p-score = 0.62), covered Evolution® stent (p-score = 0.96) and brachytherapy (p-score = 0.82) were better treatments in the network of bleeding complications. Covered Evolution® (p-score = 0.78), uncovered (p-score = 0.88) and irradiation stents (p-score = 0.65) were better treatments in network of stent migration complications. In the network of severe pain, Conventional self-expandable nitinol alloy covered stent (p-score = 0.73), polyflex (p-score = 0.79), latex prosthesis (p-score = 0.96) and brachytherapy (p-score = 0.65) were better treatments.<h4>Conclusion</h4>According to our results, thermal ablative therapy, covered Evolution® stents, brachytherapy, and antireflux stents are associated with a lower risk of TRD. Moreover, thermal ablative therapy, conventional, covered Evolution® and brachytherapy had lower risks of bleeding. Overall, fewer complications were associated with covered Evolution® stent and brachytherapy. |
| format | Article |
| id | doaj-art-a62f006d5fdb4b918a41f74466c47eb6 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-a62f006d5fdb4b918a41f74466c47eb62025-08-20T03:56:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011210e018478410.1371/journal.pone.0184784Complications of stent placement in patients with esophageal cancer: A systematic review and network meta-analysis.Amin Doosti-IraniMohammad Ali MansourniaAbbas Rahimi-ForoushaniPeiman HaddadKourosh Holakouie-Naieni<h4>Background</h4>Palliative treatments and stents are necessary for relieving dysphagia in patients with esophageal cancer. The aim of this study was to simultaneously compare available treatments in terms of complications.<h4>Methods</h4>Web of Science, Medline, Scopus, Cochrane Library and Embase were searched. Statistical heterogeneity was assessed using the Chi2 test and was quantified by I2. The results of this study were summarized in terms of Risk Ratio (RR). The random effects model was used to report the results. The rank probability for each treatment was calculated using the p-score.<h4>Results</h4>Out of 17855 references, 24 RCTs reported complications including treatment related death (TRD), bleeding, stent migration, aspiration, severe pain and fistula formation. In the ranking of treatments, thermal ablative therapy (p-score = 0.82), covered Evolution® stent (p-score = 0.70), brachytherapy (p-score = 0.72) and antireflux stent (p-score = 0.74) were better treatments in the network of TRD. Thermal ablative therapy (p-score = 0.86), the conventional stent (p-score = 0.62), covered Evolution® stent (p-score = 0.96) and brachytherapy (p-score = 0.82) were better treatments in the network of bleeding complications. Covered Evolution® (p-score = 0.78), uncovered (p-score = 0.88) and irradiation stents (p-score = 0.65) were better treatments in network of stent migration complications. In the network of severe pain, Conventional self-expandable nitinol alloy covered stent (p-score = 0.73), polyflex (p-score = 0.79), latex prosthesis (p-score = 0.96) and brachytherapy (p-score = 0.65) were better treatments.<h4>Conclusion</h4>According to our results, thermal ablative therapy, covered Evolution® stents, brachytherapy, and antireflux stents are associated with a lower risk of TRD. Moreover, thermal ablative therapy, conventional, covered Evolution® and brachytherapy had lower risks of bleeding. Overall, fewer complications were associated with covered Evolution® stent and brachytherapy.https://doi.org/10.1371/journal.pone.0184784 |
| spellingShingle | Amin Doosti-Irani Mohammad Ali Mansournia Abbas Rahimi-Foroushani Peiman Haddad Kourosh Holakouie-Naieni Complications of stent placement in patients with esophageal cancer: A systematic review and network meta-analysis. PLoS ONE |
| title | Complications of stent placement in patients with esophageal cancer: A systematic review and network meta-analysis. |
| title_full | Complications of stent placement in patients with esophageal cancer: A systematic review and network meta-analysis. |
| title_fullStr | Complications of stent placement in patients with esophageal cancer: A systematic review and network meta-analysis. |
| title_full_unstemmed | Complications of stent placement in patients with esophageal cancer: A systematic review and network meta-analysis. |
| title_short | Complications of stent placement in patients with esophageal cancer: A systematic review and network meta-analysis. |
| title_sort | complications of stent placement in patients with esophageal cancer a systematic review and network meta analysis |
| url | https://doi.org/10.1371/journal.pone.0184784 |
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