BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis
Otitis media (OM) is a prevalent childhood ear disease characterized by inflammation of the middle ear cavity, which can lead to ear pain, fever, and hearing loss. The pathogenesis of OM is multifaceted, encompassing a variety of factors including bacterial or viral infections, host immune responses...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-12-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2022-1019 |
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| author | He Qian Cai Yanzhi Kong Meihua |
| author_facet | He Qian Cai Yanzhi Kong Meihua |
| author_sort | He Qian |
| collection | DOAJ |
| description | Otitis media (OM) is a prevalent childhood ear disease characterized by inflammation of the middle ear cavity, which can lead to ear pain, fever, and hearing loss. The pathogenesis of OM is multifaceted, encompassing a variety of factors including bacterial or viral infections, host immune responses, and the function of middle ear epithelial cells. Boswellic acid (BA), a natural triterpene compound extracted from frankincense resin, has been proven to possess significant anti-inflammatory and immunomodulatory effects. This study aims to investigate the effects of BA on lipopolysaccharide (LPS)-stimulated inflammatory responses and apoptosis in human middle ear epithelial cells (HMEECs) and its potential mechanisms. Our findings demonstrated that BA enhances the proliferation of LPS-stimulated HMEECs and concurrently inhibits their apoptosis. In addition, BA blocked LPS-stimulated HMEEC inflammation. Mechanistically, BA suppressed the NF-κB/IκBα axis in LPS-stimulated HMEECs. In conclusion, BA effectively inhibits LPS-stimulated inflammation and apoptosis by mediating the NF-κB/IκBα axis, highlighting its potential as a therapeutic agent for OM. |
| format | Article |
| id | doaj-art-a62332738df440d39b9f2ac46e2e91ea |
| institution | Kabale University |
| issn | 2391-5412 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj-art-a62332738df440d39b9f2ac46e2e91ea2025-01-20T11:08:13ZengDe GruyterOpen Life Sciences2391-54122024-12-01191182510.1515/biol-2022-1019BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axisHe Qian0Cai Yanzhi1Kong Meihua2Department of ENT, Yueqing People’s Hospital, 338, Qingyuan Road, Chengnan Street, Yueqing City, Wenzhou, Zhejiang, 325600, ChinaDepartment of ENT, Yueqing People’s Hospital, 338, Qingyuan Road, Chengnan Street, Yueqing City, Wenzhou, Zhejiang, 325600, ChinaDepartment of ENT, Yueqing People’s Hospital, 338, Qingyuan Road, Chengnan Street, Yueqing City, Wenzhou, Zhejiang, 325600, ChinaOtitis media (OM) is a prevalent childhood ear disease characterized by inflammation of the middle ear cavity, which can lead to ear pain, fever, and hearing loss. The pathogenesis of OM is multifaceted, encompassing a variety of factors including bacterial or viral infections, host immune responses, and the function of middle ear epithelial cells. Boswellic acid (BA), a natural triterpene compound extracted from frankincense resin, has been proven to possess significant anti-inflammatory and immunomodulatory effects. This study aims to investigate the effects of BA on lipopolysaccharide (LPS)-stimulated inflammatory responses and apoptosis in human middle ear epithelial cells (HMEECs) and its potential mechanisms. Our findings demonstrated that BA enhances the proliferation of LPS-stimulated HMEECs and concurrently inhibits their apoptosis. In addition, BA blocked LPS-stimulated HMEEC inflammation. Mechanistically, BA suppressed the NF-κB/IκBα axis in LPS-stimulated HMEECs. In conclusion, BA effectively inhibits LPS-stimulated inflammation and apoptosis by mediating the NF-κB/IκBα axis, highlighting its potential as a therapeutic agent for OM.https://doi.org/10.1515/biol-2022-1019boswellic acidlipopolysaccharidehuman middle ear epithelial cellsinflammationnf-κb/iκbα axis |
| spellingShingle | He Qian Cai Yanzhi Kong Meihua BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis Open Life Sciences boswellic acid lipopolysaccharide human middle ear epithelial cells inflammation nf-κb/iκbα axis |
| title | BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis |
| title_full | BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis |
| title_fullStr | BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis |
| title_full_unstemmed | BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis |
| title_short | BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis |
| title_sort | ba inhibits lps stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the nf kb iκbα axis |
| topic | boswellic acid lipopolysaccharide human middle ear epithelial cells inflammation nf-κb/iκbα axis |
| url | https://doi.org/10.1515/biol-2022-1019 |
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