Models, measurement and inference in epithelial tissue dynamics
The majority of solid tumours arise in epithelia and therefore much research effort has gone into investigating the growth, renewal and regulation of these tissues. Here we review different mathematical and computational approaches that have been used to model epithelia. We compare different models...
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| Format: | Article |
| Language: | English |
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AIMS Press
2015-07-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2015.12.1321 |
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| _version_ | 1832590137576390656 |
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| author | Oliver J. Maclaren Helen M. Byrne Alexander G. Fletcher Philip K. Maini |
| author_facet | Oliver J. Maclaren Helen M. Byrne Alexander G. Fletcher Philip K. Maini |
| author_sort | Oliver J. Maclaren |
| collection | DOAJ |
| description | The majority of solid tumours arise in epithelia and therefore much research effort has gone into investigating the growth, renewal and regulation of these tissues. Here we review different mathematical and computational approaches that have been used to model epithelia. We compare different models and describe future challenges that need to be overcome in order to fully exploit new data which present, for the first time, the real possibility for detailed model validation and comparison. |
| format | Article |
| id | doaj-art-a6196f2217d24cd3a7f12f26684a612d |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-a6196f2217d24cd3a7f12f26684a612d2025-01-24T02:33:57ZengAIMS PressMathematical Biosciences and Engineering1551-00182015-07-011261321134010.3934/mbe.2015.12.1321Models, measurement and inference in epithelial tissue dynamicsOliver J. Maclaren0Helen M. Byrne1Alexander G. Fletcher2Philip K. Maini3Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Radclie Observatory Quarter, Woodstock Road, Oxford, OX2 6GGDepartment of Computer Science, University of Oxford, Wolfson Building, Parks Road, Oxford OX1 3QDWolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Radclie Observatory Quarter, Woodstock Road, Oxford, OX2 6GGWolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Radclie Observatory Quarter, Woodstock Road, Oxford, OX2 6GGThe majority of solid tumours arise in epithelia and therefore much research effort has gone into investigating the growth, renewal and regulation of these tissues. Here we review different mathematical and computational approaches that have been used to model epithelia. We compare different models and describe future challenges that need to be overcome in order to fully exploit new data which present, for the first time, the real possibility for detailed model validation and comparison.https://www.aimspress.com/article/doi/10.3934/mbe.2015.12.1321cancerinference.individual-based modellingmultiscale modellingepitheliacontinuum modellingcompartmental modelling |
| spellingShingle | Oliver J. Maclaren Helen M. Byrne Alexander G. Fletcher Philip K. Maini Models, measurement and inference in epithelial tissue dynamics Mathematical Biosciences and Engineering cancer inference. individual-based modelling multiscale modelling epithelia continuum modelling compartmental modelling |
| title | Models, measurement and inference in epithelial tissue dynamics |
| title_full | Models, measurement and inference in epithelial tissue dynamics |
| title_fullStr | Models, measurement and inference in epithelial tissue dynamics |
| title_full_unstemmed | Models, measurement and inference in epithelial tissue dynamics |
| title_short | Models, measurement and inference in epithelial tissue dynamics |
| title_sort | models measurement and inference in epithelial tissue dynamics |
| topic | cancer inference. individual-based modelling multiscale modelling epithelia continuum modelling compartmental modelling |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2015.12.1321 |
| work_keys_str_mv | AT oliverjmaclaren modelsmeasurementandinferenceinepithelialtissuedynamics AT helenmbyrne modelsmeasurementandinferenceinepithelialtissuedynamics AT alexandergfletcher modelsmeasurementandinferenceinepithelialtissuedynamics AT philipkmaini modelsmeasurementandinferenceinepithelialtissuedynamics |