A Rare Occurrence of Solid Gynecological Malignancy Synchronous with Hematological Malignancy: Rare Case and Review of Literature
A synchronous solid and hematological malignancy is an uncommon condition in which a patient develops two or more primary cancers, one of which is a solid malignancy and the other one is a hematological malignancy, within 6 months of primary cancer diagnosis. The most common histology in solid malig...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2024-10-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1775830 |
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| author | Rubi Gupta Pariseema Dave Bijal Patel Remi Abdul Shukur |
| author_facet | Rubi Gupta Pariseema Dave Bijal Patel Remi Abdul Shukur |
| author_sort | Rubi Gupta |
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| description | A synchronous solid and hematological malignancy is an uncommon condition in which a patient develops two or more primary cancers, one of which is a solid malignancy and the other one is a hematological malignancy, within 6 months of primary cancer diagnosis. The most common histology in solid malignancies is gastrointestinal adenocarcinoma, which coexists with the lymphoma subtype diffuse large B-cell lymphoma (DLBCL). Here, we report an extremely rare combination of serous carcinoma of the ovary synchronous with lymphoma of DLBCL subtype. A woman aged 52 years presented with an abdominal mass and abdominal pain for a short duration of 15 days. She was evaluated using clinical, radiological, and biochemical parameters. She was diagnosed with non-Hodgkin lymphoma by tru-cut biopsy from a bony lytic lesion and ovarian cancer by staging laparotomy. R-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisolone) chemotherapy for lymphoma and staging laparotomy for persistent adnexal mass resulted in complete remission of both ovarian cancer and lymphoma. She received paclitaxel and carboplatin-based postoperative chemotherapy as an adjuvant for ovarian cancer. |
| format | Article |
| id | doaj-art-a6156f6dbc4d4b5b94e304668877d51c |
| institution | OA Journals |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-a6156f6dbc4d4b5b94e304668877d51c2025-08-20T02:32:41ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292024-10-01450543944210.1055/s-0043-1775830A Rare Occurrence of Solid Gynecological Malignancy Synchronous with Hematological Malignancy: Rare Case and Review of LiteratureRubi Gupta0Pariseema Dave1Bijal Patel2Remi Abdul Shukur3Department of Gynaecological Oncology, Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, IndiaDepartment of Gynaecological Oncology, Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, IndiaDepartment of Gynaecological Oncology, Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, IndiaDepartment of Gynaecological Oncology, Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, IndiaA synchronous solid and hematological malignancy is an uncommon condition in which a patient develops two or more primary cancers, one of which is a solid malignancy and the other one is a hematological malignancy, within 6 months of primary cancer diagnosis. The most common histology in solid malignancies is gastrointestinal adenocarcinoma, which coexists with the lymphoma subtype diffuse large B-cell lymphoma (DLBCL). Here, we report an extremely rare combination of serous carcinoma of the ovary synchronous with lymphoma of DLBCL subtype. A woman aged 52 years presented with an abdominal mass and abdominal pain for a short duration of 15 days. She was evaluated using clinical, radiological, and biochemical parameters. She was diagnosed with non-Hodgkin lymphoma by tru-cut biopsy from a bony lytic lesion and ovarian cancer by staging laparotomy. R-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisolone) chemotherapy for lymphoma and staging laparotomy for persistent adnexal mass resulted in complete remission of both ovarian cancer and lymphoma. She received paclitaxel and carboplatin-based postoperative chemotherapy as an adjuvant for ovarian cancer.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1775830synchronous multiple primary malignancieslymphomaserous ovarian cancer |
| spellingShingle | Rubi Gupta Pariseema Dave Bijal Patel Remi Abdul Shukur A Rare Occurrence of Solid Gynecological Malignancy Synchronous with Hematological Malignancy: Rare Case and Review of Literature Indian Journal of Medical and Paediatric Oncology synchronous multiple primary malignancies lymphoma serous ovarian cancer |
| title | A Rare Occurrence of Solid Gynecological Malignancy Synchronous with Hematological Malignancy: Rare Case and Review of Literature |
| title_full | A Rare Occurrence of Solid Gynecological Malignancy Synchronous with Hematological Malignancy: Rare Case and Review of Literature |
| title_fullStr | A Rare Occurrence of Solid Gynecological Malignancy Synchronous with Hematological Malignancy: Rare Case and Review of Literature |
| title_full_unstemmed | A Rare Occurrence of Solid Gynecological Malignancy Synchronous with Hematological Malignancy: Rare Case and Review of Literature |
| title_short | A Rare Occurrence of Solid Gynecological Malignancy Synchronous with Hematological Malignancy: Rare Case and Review of Literature |
| title_sort | rare occurrence of solid gynecological malignancy synchronous with hematological malignancy rare case and review of literature |
| topic | synchronous multiple primary malignancies lymphoma serous ovarian cancer |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1775830 |
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