Sildenafil promotes osteogenic differentiation of human mesenchymal stem cells and inhibits bone loss by affecting the TGF-β signaling pathway

Sildenafil promotes osteogenic differentiation of human mesenchymal stem cells and inhibits bone loss by affecting the TGF-β signaling pathway

Abstract Background Osteoporosis, a common bone disorder, is primarily managed pharmacologically. However, existing medications are associated with non-trivial side-effects. Sildenafil, which already finds many clinical applications, promotes angiogenesis and cellular differentiation. Osteoporotic p...

Full description

Saved in:
Bibliographic Details
Main Authors: Menglong Hu, Likun Wu, Erfan Wei, Xingtong Pan, Qiyue Zhu, Xv Xiuyun, Letian Lv, Xinyi Dong, Hao Liu, Yunsong Liu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Stem Cell Research & Therapy
Subjects:
Sildenafil
Mesenchymal stem cells
Osteogenesis
Osteoporosis
TGF-β signaling pathway
Online Access:https://doi.org/10.1186/s13287-025-04320-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items