Correlation and clinical significance of placental tissue selectin (E), angiotensin II and its receptors, and oxidized lipid levels in patients with preeclampsia
Background: The purpose was to analyze the levels of placental tissue selectins (E), angiotensin II (AngII) and its receptors (ATRs), and oxidized lipids (malondialdehyde (MDA), 8-isoprostane 2a) in patients with preeclampsia (PE). (8-iso-PGF2a)) correlation and clinical significance. Methods: Selec...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| author | Yan Gao Guohong Wu Haiting Huang Xiaoyan Lu Peifen Wu Zou Suiyi Zhenyan Liu |
| author_facet | Yan Gao Guohong Wu Haiting Huang Xiaoyan Lu Peifen Wu Zou Suiyi Zhenyan Liu |
| author_sort | Yan Gao |
| collection | DOAJ |
| description | Background: The purpose was to analyze the levels of placental tissue selectins (E), angiotensin II (AngII) and its receptors (ATRs), and oxidized lipids (malondialdehyde (MDA), 8-isoprostane 2a) in patients with preeclampsia (PE). (8-iso-PGF2a)) correlation and clinical significance. Methods: Select 30 PE pregnant women who were admitted to our hospital from March 2023 to January 2024 as the case group, and select another 30 normal pregnant women who were registered in our hospital during the same period as the health group .The general information of the two groups and placental tissue selectin (E), plasma AngII, ATRs, placental tissue MDA, 8-iso-PGF2a and blood pressure levels (systolic blood pressure (SBP), diastolic blood pressure (DBP)) were compared. Pearson correlation was used to analyze the correlation between the expression of selectin (E), AngII, ATRs, MDA, 8-iso-PGF2a and the levels of SBP and DBP. ROC curves were drawn to analyze the value of placental tissue selectin (E), AngII, ATRs, MDA, and 8-iso-PGF2a individually and jointly in predicting the risk of PE. Results: The expression of placental tissue selectin (E), AngII, ATRs, MDA, 8-iso-PGF2a and the levels of SBP and DBP in the case group were higher than those in the healthy group (P<0.05). Pearson correlation showed that the expression levels of placental tissue selectin (E), AngII, ATRs, MDA, and 8-iso-PGF2a were positively correlated with SBP and DBP (r>0, P<0.05). The results of drawing the ROC curve showed that the AUCs of placental tissue selectin (E), AngII, ATRs, MDA, and 8-iso-PGF2a expression in predicting the occurrence of PE were 0.854, 0.756, 0.745, 0.885, 0.900, and 0.905 respectively. Conclusions: Placenta tissue selectin (E), AngII, ATRs, MDA, and 8-iso-PGF2a are highly expressed in pregnant women with PE. The expression of the above indicators is related to maternal blood pressure levels, and their combination can effectively increase predictive value of the risk of PE. |
| format | Article |
| id | doaj-art-a60703ac451e49c793f316ef44cf5d0b |
| institution | Kabale University |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
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| series | Journal of Medical Biochemistry |
| spelling | doaj-art-a60703ac451e49c793f316ef44cf5d0b2025-02-05T13:11:24ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144114815510.5937/jomb0-513031452-82582501148YCorrelation and clinical significance of placental tissue selectin (E), angiotensin II and its receptors, and oxidized lipid levels in patients with preeclampsiaYan Gao0Guohong Wu1Haiting Huang2Xiaoyan Lu3Peifen Wu4Zou Suiyi5Zhenyan Liu6Wuchuan People's Hospital, Wuchuan, ChinaThe Fifth People's Hospital of Shunde District, Foshan, ChinaThe Fifth People's Hospital of Shunde District, Foshan, ChinaThe Fifth People's Hospital of Shunde District, Foshan, ChinaThe Fifth People's Hospital of Shunde District, Foshan, ChinaThe Fifth People's Hospital of Shunde District, Foshan, ChinaThe Fifth People's Hospital of Shunde District, Foshan, ChinaBackground: The purpose was to analyze the levels of placental tissue selectins (E), angiotensin II (AngII) and its receptors (ATRs), and oxidized lipids (malondialdehyde (MDA), 8-isoprostane 2a) in patients with preeclampsia (PE). (8-iso-PGF2a)) correlation and clinical significance. Methods: Select 30 PE pregnant women who were admitted to our hospital from March 2023 to January 2024 as the case group, and select another 30 normal pregnant women who were registered in our hospital during the same period as the health group .The general information of the two groups and placental tissue selectin (E), plasma AngII, ATRs, placental tissue MDA, 8-iso-PGF2a and blood pressure levels (systolic blood pressure (SBP), diastolic blood pressure (DBP)) were compared. Pearson correlation was used to analyze the correlation between the expression of selectin (E), AngII, ATRs, MDA, 8-iso-PGF2a and the levels of SBP and DBP. ROC curves were drawn to analyze the value of placental tissue selectin (E), AngII, ATRs, MDA, and 8-iso-PGF2a individually and jointly in predicting the risk of PE. Results: The expression of placental tissue selectin (E), AngII, ATRs, MDA, 8-iso-PGF2a and the levels of SBP and DBP in the case group were higher than those in the healthy group (P<0.05). Pearson correlation showed that the expression levels of placental tissue selectin (E), AngII, ATRs, MDA, and 8-iso-PGF2a were positively correlated with SBP and DBP (r>0, P<0.05). The results of drawing the ROC curve showed that the AUCs of placental tissue selectin (E), AngII, ATRs, MDA, and 8-iso-PGF2a expression in predicting the occurrence of PE were 0.854, 0.756, 0.745, 0.885, 0.900, and 0.905 respectively. Conclusions: Placenta tissue selectin (E), AngII, ATRs, MDA, and 8-iso-PGF2a are highly expressed in pregnant women with PE. The expression of the above indicators is related to maternal blood pressure levels, and their combination can effectively increase predictive value of the risk of PE.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501148Y.pdfpreeclampsiaplacental tissue selectin (e)angiotensin ii and its receptorsoxidized lipidsblood pressurepredictive value |
| spellingShingle | Yan Gao Guohong Wu Haiting Huang Xiaoyan Lu Peifen Wu Zou Suiyi Zhenyan Liu Correlation and clinical significance of placental tissue selectin (E), angiotensin II and its receptors, and oxidized lipid levels in patients with preeclampsia Journal of Medical Biochemistry preeclampsia placental tissue selectin (e) angiotensin ii and its receptors oxidized lipids blood pressure predictive value |
| title | Correlation and clinical significance of placental tissue selectin (E), angiotensin II and its receptors, and oxidized lipid levels in patients with preeclampsia |
| title_full | Correlation and clinical significance of placental tissue selectin (E), angiotensin II and its receptors, and oxidized lipid levels in patients with preeclampsia |
| title_fullStr | Correlation and clinical significance of placental tissue selectin (E), angiotensin II and its receptors, and oxidized lipid levels in patients with preeclampsia |
| title_full_unstemmed | Correlation and clinical significance of placental tissue selectin (E), angiotensin II and its receptors, and oxidized lipid levels in patients with preeclampsia |
| title_short | Correlation and clinical significance of placental tissue selectin (E), angiotensin II and its receptors, and oxidized lipid levels in patients with preeclampsia |
| title_sort | correlation and clinical significance of placental tissue selectin e angiotensin ii and its receptors and oxidized lipid levels in patients with preeclampsia |
| topic | preeclampsia placental tissue selectin (e) angiotensin ii and its receptors oxidized lipids blood pressure predictive value |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582501148Y.pdf |
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