Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-Labeled Reporter Nanoparticles
Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal nanoparticle ( 89 Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DOX) delivery in mouse tumors. I...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-02-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012117749726 |
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| author | Govindarajan Srimathveeravalli PhD Dalya Abdel-Atti BS Carlos Pérez-Medina PhD Haruyuki Takaki MD, PhD Stephen B. Solomon MD Willem J. M. Mulder PhD Thomas Reiner PhD |
| author_facet | Govindarajan Srimathveeravalli PhD Dalya Abdel-Atti BS Carlos Pérez-Medina PhD Haruyuki Takaki MD, PhD Stephen B. Solomon MD Willem J. M. Mulder PhD Thomas Reiner PhD |
| author_sort | Govindarajan Srimathveeravalli PhD |
| collection | DOAJ |
| description | Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal nanoparticle ( 89 Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DOX) delivery in mouse tumors. Intravenously delivered 89 Zr-NRep allowed positron emission tomography imaging of electroporation-mediated nanoparticle uptake. The relative order of 89 Zr-NRep injection and electroporation did not result in significantly different overall tumor uptake, suggesting direct transfection and vascular permeability can independently mediate deposition of 89 Zr-NRep in tumors. 89 Zr-NRep and DOX uptake correlated well in both electroporated and control tumors at all experimental time points. Electroporation accelerated 89 Zr-NRep and DOX deposition into tumors and increased DOX dosing. Reversible electroporation–related vascular effects seem to play an important role in nanoparticle delivery to tumors and drug uptake can be quantified with 89 Zr-NRep. |
| format | Article |
| id | doaj-art-a5ff8c1c9dcb49608340b24fb6d0c6f0 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2018-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-a5ff8c1c9dcb49608340b24fb6d0c6f02025-02-03T10:07:59ZengSAGE PublishingMolecular Imaging1536-01212018-02-011710.1177/1536012117749726Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-Labeled Reporter NanoparticlesGovindarajan Srimathveeravalli PhD0Dalya Abdel-Atti BS1Carlos Pérez-Medina PhD2Haruyuki Takaki MD, PhD3Stephen B. Solomon MD4Willem J. M. Mulder PhD5Thomas Reiner PhD6 Department of Radiology, Weill-Cornell Medical College, New York, NY, USA Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA Department of Radiology, Hyogo College of Medicine, Hyogo, Japan Department of Radiology, Weill-Cornell Medical College, New York, NY, USA Department of Medical Biochemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands Department of Radiology, Weill-Cornell Medical College, New York, NY, USAReversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal nanoparticle ( 89 Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DOX) delivery in mouse tumors. Intravenously delivered 89 Zr-NRep allowed positron emission tomography imaging of electroporation-mediated nanoparticle uptake. The relative order of 89 Zr-NRep injection and electroporation did not result in significantly different overall tumor uptake, suggesting direct transfection and vascular permeability can independently mediate deposition of 89 Zr-NRep in tumors. 89 Zr-NRep and DOX uptake correlated well in both electroporated and control tumors at all experimental time points. Electroporation accelerated 89 Zr-NRep and DOX deposition into tumors and increased DOX dosing. Reversible electroporation–related vascular effects seem to play an important role in nanoparticle delivery to tumors and drug uptake can be quantified with 89 Zr-NRep.https://doi.org/10.1177/1536012117749726 |
| spellingShingle | Govindarajan Srimathveeravalli PhD Dalya Abdel-Atti BS Carlos Pérez-Medina PhD Haruyuki Takaki MD, PhD Stephen B. Solomon MD Willem J. M. Mulder PhD Thomas Reiner PhD Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-Labeled Reporter Nanoparticles Molecular Imaging |
| title | Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-Labeled Reporter Nanoparticles |
| title_full | Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-Labeled Reporter Nanoparticles |
| title_fullStr | Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-Labeled Reporter Nanoparticles |
| title_full_unstemmed | Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-Labeled Reporter Nanoparticles |
| title_short | Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-Labeled Reporter Nanoparticles |
| title_sort | reversible electroporation mediated liposomal doxorubicin delivery to tumors can be monitored with zr labeled reporter nanoparticles |
| url | https://doi.org/10.1177/1536012117749726 |
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