Generation of two induced pluripotent stem cell lines to model and investigate diseases affecting Pacific Islanders
Pacific Islanders (PI) comprise only 0.4% of the US population, yet they have amongst the highest prevalence of diseases. They are historically underreported in medical literature and underrepresented in clinical investigation. Increased representation in clinical datasets can mitigate disparities a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Stem Cell Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506125000182 |
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| author | Angela Zhang James W.S. Jahng Julio V. Guevara Christopher D. Yan Michael V. McConnell Joseph C. Wu |
| author_facet | Angela Zhang James W.S. Jahng Julio V. Guevara Christopher D. Yan Michael V. McConnell Joseph C. Wu |
| author_sort | Angela Zhang |
| collection | DOAJ |
| description | Pacific Islanders (PI) comprise only 0.4% of the US population, yet they have amongst the highest prevalence of diseases. They are historically underreported in medical literature and underrepresented in clinical investigation. Increased representation in clinical datasets can mitigate disparities and address differential health outcomes. In recent years, induced pluripotent stem cells (iPSCs) have become a popular platform for disease and drug investigation. Here, we generate two iPSC lines from the peripheral blood mononuclear cells (PBMCs) of healthy PI patients. We demonstrate that the lines exhibit normal morphology and karyotypes, robust expression of pluripotent markers, and the capacity for trilineage differentiation. |
| format | Article |
| id | doaj-art-a5f5e3df118a4a6d99c6f186afa6c091 |
| institution | Kabale University |
| issn | 1873-5061 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj-art-a5f5e3df118a4a6d99c6f186afa6c0912025-02-06T05:11:27ZengElsevierStem Cell Research1873-50612025-03-0183103668Generation of two induced pluripotent stem cell lines to model and investigate diseases affecting Pacific IslandersAngela Zhang0James W.S. Jahng1Julio V. Guevara2Christopher D. Yan3Michael V. McConnell4Joseph C. Wu5Stanford Cardiovascular Institute, Stanford, CA 94305, United States; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, United States; Department of Computer Science, Stanford University School of Engineering, Stanford, CA 94305, United StatesStanford Cardiovascular Institute, Stanford, CA 94305, United States; Department of Medicine, Division of Cardiovascular Medicine, Palo Alto, CA 94304, United StatesStanford Cardiovascular Institute, Stanford, CA 94305, United StatesGreenstone Biosciences, Palo Alto, CA 94304, United StatesStanford Cardiovascular Institute, Stanford, CA 94305, United States; Department of Medicine, Division of Cardiovascular Medicine, Palo Alto, CA 94304, United StatesStanford Cardiovascular Institute, Stanford, CA 94305, United States; Department of Medicine, Division of Cardiovascular Medicine, Palo Alto, CA 94304, United States; Corresponding author at: 265 Campus Drive G1120B, Stanford, CA 94305, United States.Pacific Islanders (PI) comprise only 0.4% of the US population, yet they have amongst the highest prevalence of diseases. They are historically underreported in medical literature and underrepresented in clinical investigation. Increased representation in clinical datasets can mitigate disparities and address differential health outcomes. In recent years, induced pluripotent stem cells (iPSCs) have become a popular platform for disease and drug investigation. Here, we generate two iPSC lines from the peripheral blood mononuclear cells (PBMCs) of healthy PI patients. We demonstrate that the lines exhibit normal morphology and karyotypes, robust expression of pluripotent markers, and the capacity for trilineage differentiation.http://www.sciencedirect.com/science/article/pii/S1873506125000182Stem cellsDisease modelingDrug screeningPacific Islanders |
| spellingShingle | Angela Zhang James W.S. Jahng Julio V. Guevara Christopher D. Yan Michael V. McConnell Joseph C. Wu Generation of two induced pluripotent stem cell lines to model and investigate diseases affecting Pacific Islanders Stem Cell Research Stem cells Disease modeling Drug screening Pacific Islanders |
| title | Generation of two induced pluripotent stem cell lines to model and investigate diseases affecting Pacific Islanders |
| title_full | Generation of two induced pluripotent stem cell lines to model and investigate diseases affecting Pacific Islanders |
| title_fullStr | Generation of two induced pluripotent stem cell lines to model and investigate diseases affecting Pacific Islanders |
| title_full_unstemmed | Generation of two induced pluripotent stem cell lines to model and investigate diseases affecting Pacific Islanders |
| title_short | Generation of two induced pluripotent stem cell lines to model and investigate diseases affecting Pacific Islanders |
| title_sort | generation of two induced pluripotent stem cell lines to model and investigate diseases affecting pacific islanders |
| topic | Stem cells Disease modeling Drug screening Pacific Islanders |
| url | http://www.sciencedirect.com/science/article/pii/S1873506125000182 |
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