Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP

Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP

Aryl organophosphorus flame retardants (aryl-OPFRs), commonly used product additives with close ties to daily life, have been regrettably characterized by multiple well-defined toxicity risks. Triphenyl phosphate (TPHP) and tri-o-cresyl phosphate (TOCP), two structurally similar aryl-OPFRs, were obs...

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Bibliographic Details
Main Authors: Bilin Zhao, Shuang Zheng, Gaoxiang Yang, Zhijun He, Jiewei Deng, Lijuan Luo, Xinyan Li, Tiangang Luan
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Environment International
Subjects:
Aryl-OPFRs
TPHP
TOCP
Macrophage
Immunotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S016041202400802X
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