Real-World Data Confirm That the Integration of Deuterium Depletion into Conventional Cancer Therapy Multiplies the Survival Probability of Patients
<b>Background</b>: Over thirty years of basic research has demonstrated that the deuterium-to-hydrogen ratio plays a pivotal role in regulating metabolism and cell growth via a sub-molecular regulatory system that orchestrates the intricate complexity of life in eukaryotic organisms. Deu...
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MDPI AG
2025-04-01
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| Online Access: | https://www.mdpi.com/2227-9059/13/4/876 |
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| author | Gábor Somlyai András Papp Ildikó Somlyai Beáta Zs Kovács Mária Debrődi |
| author_facet | Gábor Somlyai András Papp Ildikó Somlyai Beáta Zs Kovács Mária Debrődi |
| author_sort | Gábor Somlyai |
| collection | DOAJ |
| description | <b>Background</b>: Over thirty years of basic research has demonstrated that the deuterium-to-hydrogen ratio plays a pivotal role in regulating metabolism and cell growth via a sub-molecular regulatory system that orchestrates the intricate complexity of life in eukaryotic organisms. Deuterium depletion, achieved through deuterium-depleted water (DDW), has shown anticancer effects in vitro, in vivo, and in Phase 2 prospective and retrospective clinical studies. <b>Methods</b>: In this population-based observational study, 2649 cancer patients undergoing conventional therapy and consuming DDW were included between October 1992 and October 2024. With various cancer types and stages and conventional therapies received, they are representing a broad spectrum of the Hungarian cancer population. Survival was selected as the primary endpoint, and the median survival time (MST) of these patients and various subgroups was calculated and compared to the overall Hungarian cancer population’s MST of 2.4 years. <b>Results</b>: For the entire study population, MST from diagnosis was 12.4 years (95% CI: 9.8–14.9), and from the initiation of DDW treatment, 7.6 years (95% CI: 5.9–9.3). <b>Conclusions</b>: Utilizing DDW enables targeted intervention in the sub-molecular regulatory system, paving the way for innovative therapeutic applications and a more profound understanding of cellular processes. Integrating deuterium depletion into conventional cancer therapies has the potential to significantly enhance survival rates and reduce cancer-related mortality by 75–80%. |
| format | Article |
| id | doaj-art-a5e1e8e7ea0b46c48f1a36a6da89d8f1 |
| institution | OA Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-a5e1e8e7ea0b46c48f1a36a6da89d8f12025-08-20T02:17:20ZengMDPI AGBiomedicines2227-90592025-04-0113487610.3390/biomedicines13040876Real-World Data Confirm That the Integration of Deuterium Depletion into Conventional Cancer Therapy Multiplies the Survival Probability of PatientsGábor Somlyai0András Papp1Ildikó Somlyai2Beáta Zs Kovács3Mária Debrődi4HYD LLC for Cancer Research and Drug Development, Villányi út 97, 1118 Budapest, HungaryDepartment of Public Health, Faculty of Medicine, University of Szeged, 6720 Szeged, HungaryHYD LLC for Cancer Research and Drug Development, Villányi út 97, 1118 Budapest, HungaryHYD LLC for Cancer Research and Drug Development, Villányi út 97, 1118 Budapest, HungaryHYD LLC for Cancer Research and Drug Development, Villányi út 97, 1118 Budapest, Hungary<b>Background</b>: Over thirty years of basic research has demonstrated that the deuterium-to-hydrogen ratio plays a pivotal role in regulating metabolism and cell growth via a sub-molecular regulatory system that orchestrates the intricate complexity of life in eukaryotic organisms. Deuterium depletion, achieved through deuterium-depleted water (DDW), has shown anticancer effects in vitro, in vivo, and in Phase 2 prospective and retrospective clinical studies. <b>Methods</b>: In this population-based observational study, 2649 cancer patients undergoing conventional therapy and consuming DDW were included between October 1992 and October 2024. With various cancer types and stages and conventional therapies received, they are representing a broad spectrum of the Hungarian cancer population. Survival was selected as the primary endpoint, and the median survival time (MST) of these patients and various subgroups was calculated and compared to the overall Hungarian cancer population’s MST of 2.4 years. <b>Results</b>: For the entire study population, MST from diagnosis was 12.4 years (95% CI: 9.8–14.9), and from the initiation of DDW treatment, 7.6 years (95% CI: 5.9–9.3). <b>Conclusions</b>: Utilizing DDW enables targeted intervention in the sub-molecular regulatory system, paving the way for innovative therapeutic applications and a more profound understanding of cellular processes. Integrating deuterium depletion into conventional cancer therapies has the potential to significantly enhance survival rates and reduce cancer-related mortality by 75–80%.https://www.mdpi.com/2227-9059/13/4/876deuteriumdeuterium-depleted watermedian survival timecancersub-molecular regulatory system |
| spellingShingle | Gábor Somlyai András Papp Ildikó Somlyai Beáta Zs Kovács Mária Debrődi Real-World Data Confirm That the Integration of Deuterium Depletion into Conventional Cancer Therapy Multiplies the Survival Probability of Patients Biomedicines deuterium deuterium-depleted water median survival time cancer sub-molecular regulatory system |
| title | Real-World Data Confirm That the Integration of Deuterium Depletion into Conventional Cancer Therapy Multiplies the Survival Probability of Patients |
| title_full | Real-World Data Confirm That the Integration of Deuterium Depletion into Conventional Cancer Therapy Multiplies the Survival Probability of Patients |
| title_fullStr | Real-World Data Confirm That the Integration of Deuterium Depletion into Conventional Cancer Therapy Multiplies the Survival Probability of Patients |
| title_full_unstemmed | Real-World Data Confirm That the Integration of Deuterium Depletion into Conventional Cancer Therapy Multiplies the Survival Probability of Patients |
| title_short | Real-World Data Confirm That the Integration of Deuterium Depletion into Conventional Cancer Therapy Multiplies the Survival Probability of Patients |
| title_sort | real world data confirm that the integration of deuterium depletion into conventional cancer therapy multiplies the survival probability of patients |
| topic | deuterium deuterium-depleted water median survival time cancer sub-molecular regulatory system |
| url | https://www.mdpi.com/2227-9059/13/4/876 |
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