Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer
Abstract Impressive clinical benefit is seen in clinic with PD‐1 inhibitors on portion of cancer patients. Yet, there remains an urgent need to develop effective synergizers to expand their clinical application. Tumor‐associated macrophage (TAM), a type of M2‐polarized macrophage, eliminates or supp...
Saved in:
| Main Authors: | Qian Zhou, Jinxia Liang, Tong Yang, Jin Liu, Bo Li, Yingchang Li, Zhenzhen Fan, Weida Wang, Wensheng Chen, Sujing Yuan, Meng Xu, Qigui Xu, Zhidong Luan, Zhongjun Xia, Penghui Zhou, Yadong Huang, Liang Chen |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2021-12-01
|
| Series: | EMBO Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.15252/emmm.202114502 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Tailoring of Albumin Nanoparticles Modified with Mannose for Effective Targeting in Immunosuppressive Tumor Microenvironment
by: Alyona B. Kuznetsova, et al.
Published: (2025-06-01) -
Revisiting TAM polarization: beyond M1- and M2-type TAM toward clinical precision in macrophage-targeted therapy
by: Qingqing Wang, et al.
Published: (2025-09-01) -
Development of anti-cancer drugs for tumor-associated macrophages: a comprehensive review and mechanistic insights
by: Bingjun Bai, et al.
Published: (2024-12-01) -
Single-cell and transcriptome analyses revealed CTHRC1 a potential therapeutic target mediating invasion and tumor microenvironment in TNBC: experimental validation
by: Hong Wan, et al.
Published: (2025-03-01) -
Characterizing macrophage diversity in colorectal malignancies through single-cell genomics
by: Tingshuo Zhao, et al.
Published: (2025-03-01)