A Complementary Dual‐Mode Ion‐Electron Conductive Hydrogel Enables Sustained Conductivity for Prolonged Electroencephalogram Recording
Abstract Conductive gel interface materials are widely employed as reliable agents for electroencephalogram (EEG) recording. However, prolonged EEG recording poses challenges in maintaining stable and efficient capture due to inevitable evaporation in hydrogels, which restricts sustained high conduc...
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| Format: | Article |
| Language: | English |
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Wiley
2024-10-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202405273 |
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| author | Hengjie Su Linna Mao Xiaoqi Chen Peishuai Liu Jiangbo Pu Zhuo Mao Tomoko Fujiwara Yue Ma Xinyang Mao Ting Li |
| author_facet | Hengjie Su Linna Mao Xiaoqi Chen Peishuai Liu Jiangbo Pu Zhuo Mao Tomoko Fujiwara Yue Ma Xinyang Mao Ting Li |
| author_sort | Hengjie Su |
| collection | DOAJ |
| description | Abstract Conductive gel interface materials are widely employed as reliable agents for electroencephalogram (EEG) recording. However, prolonged EEG recording poses challenges in maintaining stable and efficient capture due to inevitable evaporation in hydrogels, which restricts sustained high conductivity. This study introduces a novel ion‐electron dual‐mode conductive hydrogel synthesized through a cost‐effective and streamlined process. By embedding graphite nanoparticles into ionic hyaluronic acid (HAGN), the hydrogel maintains higher conductivity for over 72 h, outperforming commercial gels. Additionally, it exhibits superior low skin contact impedance, considerable electrochemical capability, and excellent tensile and adhesion performance in both dry and wet conditions. The biocompatibility of the HAGN hydrogel, verified through in vitro cell viability assays and in vivo skin irritation tests, underscores its suitability for prolonged skin contact without eliciting adverse reactions. Furthermore, in vivo EEG tests confirm the HAGN hydrogel's capability to provide high‐fidelity signal acquisition across multiple EEG protocols. The HAGN hydrogel proves to be an effective interface for prolonged high‐quality EEG recording, facilitating high‐performance capture and classification of evoked potentials, thereby providing a reliable conductive medium for EEG‐based systems. |
| format | Article |
| id | doaj-art-a5de38579c5b408ca269d5abd34d599d |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-a5de38579c5b408ca269d5abd34d599d2025-08-20T02:17:10ZengWileyAdvanced Science2198-38442024-10-011138n/an/a10.1002/advs.202405273A Complementary Dual‐Mode Ion‐Electron Conductive Hydrogel Enables Sustained Conductivity for Prolonged Electroencephalogram RecordingHengjie Su0Linna Mao1Xiaoqi Chen2Peishuai Liu3Jiangbo Pu4Zhuo Mao5Tomoko Fujiwara6Yue Ma7Xinyang Mao8Ting Li9Institute of Biomedical Engineering Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300192 ChinaInstitute of Biomedical Engineering Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300192 ChinaInstitute of Biomedical Engineering Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300192 ChinaInstitute of Biomedical Engineering Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300192 ChinaInstitute of Biomedical Engineering Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300192 ChinaInstitute of Biomedical Engineering Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300192 ChinaDepartment of Chemistry The University of Memphis Memphis TN 38152 USAInstitute of Biomedical Engineering Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300192 ChinaDepartment of Biomedical Engineering Tianjin Medical University Tianjin 301700 ChinaInstitute of Biomedical Engineering Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300192 ChinaAbstract Conductive gel interface materials are widely employed as reliable agents for electroencephalogram (EEG) recording. However, prolonged EEG recording poses challenges in maintaining stable and efficient capture due to inevitable evaporation in hydrogels, which restricts sustained high conductivity. This study introduces a novel ion‐electron dual‐mode conductive hydrogel synthesized through a cost‐effective and streamlined process. By embedding graphite nanoparticles into ionic hyaluronic acid (HAGN), the hydrogel maintains higher conductivity for over 72 h, outperforming commercial gels. Additionally, it exhibits superior low skin contact impedance, considerable electrochemical capability, and excellent tensile and adhesion performance in both dry and wet conditions. The biocompatibility of the HAGN hydrogel, verified through in vitro cell viability assays and in vivo skin irritation tests, underscores its suitability for prolonged skin contact without eliciting adverse reactions. Furthermore, in vivo EEG tests confirm the HAGN hydrogel's capability to provide high‐fidelity signal acquisition across multiple EEG protocols. The HAGN hydrogel proves to be an effective interface for prolonged high‐quality EEG recording, facilitating high‐performance capture and classification of evoked potentials, thereby providing a reliable conductive medium for EEG‐based systems.https://doi.org/10.1002/advs.202405273conductive hydrogeldual‐mode conducting mechanismelectroencephalogram (EEG)graphite nanoparticleshyaluronic acid |
| spellingShingle | Hengjie Su Linna Mao Xiaoqi Chen Peishuai Liu Jiangbo Pu Zhuo Mao Tomoko Fujiwara Yue Ma Xinyang Mao Ting Li A Complementary Dual‐Mode Ion‐Electron Conductive Hydrogel Enables Sustained Conductivity for Prolonged Electroencephalogram Recording Advanced Science conductive hydrogel dual‐mode conducting mechanism electroencephalogram (EEG) graphite nanoparticles hyaluronic acid |
| title | A Complementary Dual‐Mode Ion‐Electron Conductive Hydrogel Enables Sustained Conductivity for Prolonged Electroencephalogram Recording |
| title_full | A Complementary Dual‐Mode Ion‐Electron Conductive Hydrogel Enables Sustained Conductivity for Prolonged Electroencephalogram Recording |
| title_fullStr | A Complementary Dual‐Mode Ion‐Electron Conductive Hydrogel Enables Sustained Conductivity for Prolonged Electroencephalogram Recording |
| title_full_unstemmed | A Complementary Dual‐Mode Ion‐Electron Conductive Hydrogel Enables Sustained Conductivity for Prolonged Electroencephalogram Recording |
| title_short | A Complementary Dual‐Mode Ion‐Electron Conductive Hydrogel Enables Sustained Conductivity for Prolonged Electroencephalogram Recording |
| title_sort | complementary dual mode ion electron conductive hydrogel enables sustained conductivity for prolonged electroencephalogram recording |
| topic | conductive hydrogel dual‐mode conducting mechanism electroencephalogram (EEG) graphite nanoparticles hyaluronic acid |
| url | https://doi.org/10.1002/advs.202405273 |
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