Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian Population
Type 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary predisposition, so both environmental and genetic factors contribute to its development. Recent studies have demonstrated that the skeleton realizes systemic regulation of energy metabolism through the secretion of osteocalcin (...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2019/9302636 |
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| author | Yaroslav D. Chumachenko Viktoriia Yu. Harbuzova Alexander V. Ataman |
| author_facet | Yaroslav D. Chumachenko Viktoriia Yu. Harbuzova Alexander V. Ataman |
| author_sort | Yaroslav D. Chumachenko |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary predisposition, so both environmental and genetic factors contribute to its development. Recent studies have demonstrated that the skeleton realizes systemic regulation of energy metabolism through the secretion of osteocalcin (OCN). Thus, the association analysis between HindIII single nucleotide polymorphism of OCN gene (BGLAP) promoter region and T2DM development in Ukrainian population was carried out. 153 individuals diagnosed with T2DM and 311 control individuals were enrolled in the study. The genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The lack of association between BGLAP HindIII single nucleotide polymorphism (SNP) and T2DM development among Ukrainians was found. Further studies with extended groups of comparison are needed to confirm the obtained results. |
| format | Article |
| id | doaj-art-a5dcd9fc061744b4832bfbaa1575a29c |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-a5dcd9fc061744b4832bfbaa1575a29c2025-02-03T06:07:23ZengWileyJournal of Diabetes Research2314-67452314-67532019-01-01201910.1155/2019/93026369302636Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian PopulationYaroslav D. Chumachenko0Viktoriia Yu. Harbuzova1Alexander V. Ataman2Scientific Laboratory of Molecular Genetic Studies, Medical Institute of the Sumy State University, 40007, UkraineScientific Laboratory of Molecular Genetic Studies, Medical Institute of the Sumy State University, 40007, UkraineDepartment of Physiology and Pathophysiology with Medical Biology Course, Medical Institute of the Sumy State University, 40018, UkraineType 2 diabetes mellitus (T2DM) belongs to the diseases with hereditary predisposition, so both environmental and genetic factors contribute to its development. Recent studies have demonstrated that the skeleton realizes systemic regulation of energy metabolism through the secretion of osteocalcin (OCN). Thus, the association analysis between HindIII single nucleotide polymorphism of OCN gene (BGLAP) promoter region and T2DM development in Ukrainian population was carried out. 153 individuals diagnosed with T2DM and 311 control individuals were enrolled in the study. The genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The lack of association between BGLAP HindIII single nucleotide polymorphism (SNP) and T2DM development among Ukrainians was found. Further studies with extended groups of comparison are needed to confirm the obtained results.http://dx.doi.org/10.1155/2019/9302636 |
| spellingShingle | Yaroslav D. Chumachenko Viktoriia Yu. Harbuzova Alexander V. Ataman Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian Population Journal of Diabetes Research |
| title | Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian Population |
| title_full | Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian Population |
| title_fullStr | Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian Population |
| title_full_unstemmed | Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian Population |
| title_short | Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian Population |
| title_sort | association study between bglap gene hindiii polymorphism and type 2 diabetes mellitus development in ukrainian population |
| url | http://dx.doi.org/10.1155/2019/9302636 |
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