Serum alpha-fetoprotein levels in neonatal cholestasis
Alpha-fetoprotein (AFP) is used as a tumor marker for hepatocellular carcinoma, hepatoblastoma and germ cell tumors. It may also be elevated in infants with some hepatobiliary disorders. The mechanism of AFP elevation in neonatal cholestasis is not known. We retrospectively evaluated serum AF...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2013-04-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1473 |
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| author | Hülya Demir Gülin Hızal Nuray Uslu Kızılkan Figen Gürakan Beril Talim Turgay Coşkun Gülsev Kale Aysel Yüce |
| author_facet | Hülya Demir Gülin Hızal Nuray Uslu Kızılkan Figen Gürakan Beril Talim Turgay Coşkun Gülsev Kale Aysel Yüce |
| author_sort | Hülya Demir |
| collection | DOAJ |
| description |
Alpha-fetoprotein (AFP) is used as a tumor marker for hepatocellular carcinoma, hepatoblastoma and germ cell tumors. It may also be elevated in infants with some hepatobiliary disorders. The mechanism of AFP elevation in neonatal cholestasis is not known. We retrospectively evaluated serum AFP levels in 53 infants with neonatal cholestasis. Thirty patients (56.6%) had elevated AFP, and the ratio of patients with elevated AFP was significantly high in both the metabolic diseases and idiopathic neonatal hepatitis groups (p=0.021). Serum aspartate aminotransferase (AST) levels increased significantly in patients with elevated AFP (p=0.004). Steatosis was the distinctive histopathological finding of the patients with high AFP. The patients with steatosis had significantly higher standard deviation (SD) score of AFP than the patients without steatosis (p=0.001). We have shown AFP elevation in neonatal cholestasis due to metabolic disorders and idiopathic neonatal hepatitis and its association with steatosis and AST elevation.
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| format | Article |
| id | doaj-art-a5d87c521f724d2f8b4c8e5e0ece5a62 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2013-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-a5d87c521f724d2f8b4c8e5e0ece5a622025-08-20T03:16:22ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212013-04-01552Serum alpha-fetoprotein levels in neonatal cholestasisHülya Demir0Gülin HızalNuray Uslu KızılkanFigen GürakanBeril TalimTurgay CoşkunGülsev KaleAysel YüceDivision of Pediatric Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Turkey. hudemir@hacettepe.edu.tr. Alpha-fetoprotein (AFP) is used as a tumor marker for hepatocellular carcinoma, hepatoblastoma and germ cell tumors. It may also be elevated in infants with some hepatobiliary disorders. The mechanism of AFP elevation in neonatal cholestasis is not known. We retrospectively evaluated serum AFP levels in 53 infants with neonatal cholestasis. Thirty patients (56.6%) had elevated AFP, and the ratio of patients with elevated AFP was significantly high in both the metabolic diseases and idiopathic neonatal hepatitis groups (p=0.021). Serum aspartate aminotransferase (AST) levels increased significantly in patients with elevated AFP (p=0.004). Steatosis was the distinctive histopathological finding of the patients with high AFP. The patients with steatosis had significantly higher standard deviation (SD) score of AFP than the patients without steatosis (p=0.001). We have shown AFP elevation in neonatal cholestasis due to metabolic disorders and idiopathic neonatal hepatitis and its association with steatosis and AST elevation. https://turkjpediatr.org/article/view/1473 |
| spellingShingle | Hülya Demir Gülin Hızal Nuray Uslu Kızılkan Figen Gürakan Beril Talim Turgay Coşkun Gülsev Kale Aysel Yüce Serum alpha-fetoprotein levels in neonatal cholestasis The Turkish Journal of Pediatrics |
| title | Serum alpha-fetoprotein levels in neonatal cholestasis |
| title_full | Serum alpha-fetoprotein levels in neonatal cholestasis |
| title_fullStr | Serum alpha-fetoprotein levels in neonatal cholestasis |
| title_full_unstemmed | Serum alpha-fetoprotein levels in neonatal cholestasis |
| title_short | Serum alpha-fetoprotein levels in neonatal cholestasis |
| title_sort | serum alpha fetoprotein levels in neonatal cholestasis |
| url | https://turkjpediatr.org/article/view/1473 |
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