Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers
Determining the relationships between miRNA expression, target genes, and cancer development is critical to cancer research. The possibility of correlating miRNA expression with plant or artificial ones provides prerequisites for cancer treatment. Based on the broad database of human miRNA expressio...
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MDPI AG
2025-01-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/47/1/42 |
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| author | Maksym Zoziuk Vittorio Colizzi Pavlo Krysenko Maurizio Mattei Roberta Bernardini Fabio Massimo Zanzotto Stefano Marini Dmitri Koroliouk |
| author_facet | Maksym Zoziuk Vittorio Colizzi Pavlo Krysenko Maurizio Mattei Roberta Bernardini Fabio Massimo Zanzotto Stefano Marini Dmitri Koroliouk |
| author_sort | Maksym Zoziuk |
| collection | DOAJ |
| description | Determining the relationships between miRNA expression, target genes, and cancer development is critical to cancer research. The possibility of correlating miRNA expression with plant or artificial ones provides prerequisites for cancer treatment. Based on the broad database of human miRNA expression for all cancer types, we grade human miRNAs by their expression level. The identified deficient miRNAs are compared with their target genes for coincidences in their expression directions. The replacement of human miRNAs is proposed to be implemented, using plant miRNAs closest to the human-deficient ones. Such plant substitutes are identified by analyzing the average complementarity of all human under-expressed miRNAs. It was established that the number of downregulated miRNAs is almost 2.5 times greater than that of upregulated miRNAs. There is no significant correlation between the expression of miRNA and genes, implying many other expression regulation mechanisms exist. Working on the organization of experimental verification of the obtained statistical studies, we present significant regularities that provide grounds for considering some plant microRNAs as possible means of compensating for insufficient expression of regulatory microRNAs in humans and animals in a wide range of oncological diseases. |
| format | Article |
| id | doaj-art-a5d73bded7374aca9118520a6ff9fd91 |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-a5d73bded7374aca9118520a6ff9fd912025-01-24T13:27:30ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-01-014714210.3390/cimb47010042Plant miRNAs for Improved Gene Regulation in a Wide Range of Human CancersMaksym Zoziuk0Vittorio Colizzi1Pavlo Krysenko2Maurizio Mattei3Roberta Bernardini4Fabio Massimo Zanzotto5Stefano Marini6Dmitri Koroliouk7Centro Interdipartimentale di Medicina Comparata, Tecniche Alternative ed Acquacoltura, Interdepartmental Center for Comparative Medicine, Alternative Techniques, and Aquaculture, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyUNESCO Chair in Interdisciplinary Biotechnology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00173 Rome, ItalyInstitute of Telecommunications and Global Information Space of the National Academy of Sciences of Ukraine, Chokolivskiy bulv. 13, 03186 Kyiv, UkraineCentro Interdipartimentale di Medicina Comparata, Tecniche Alternative ed Acquacoltura, Interdepartmental Center for Comparative Medicine, Alternative Techniques, and Aquaculture, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyFaculty of Medicine, Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Roma, ItalyDepartment of Business Engineering “Mario Lucertini”, University of Rome Tor Vergata, Via del Politecnico, 1, 00133 Rome, ItalyFaculty of Medicine, Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Roma, ItalyCentro Interdipartimentale di Medicina Comparata, Tecniche Alternative ed Acquacoltura, Interdepartmental Center for Comparative Medicine, Alternative Techniques, and Aquaculture, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyDetermining the relationships between miRNA expression, target genes, and cancer development is critical to cancer research. The possibility of correlating miRNA expression with plant or artificial ones provides prerequisites for cancer treatment. Based on the broad database of human miRNA expression for all cancer types, we grade human miRNAs by their expression level. The identified deficient miRNAs are compared with their target genes for coincidences in their expression directions. The replacement of human miRNAs is proposed to be implemented, using plant miRNAs closest to the human-deficient ones. Such plant substitutes are identified by analyzing the average complementarity of all human under-expressed miRNAs. It was established that the number of downregulated miRNAs is almost 2.5 times greater than that of upregulated miRNAs. There is no significant correlation between the expression of miRNA and genes, implying many other expression regulation mechanisms exist. Working on the organization of experimental verification of the obtained statistical studies, we present significant regularities that provide grounds for considering some plant microRNAs as possible means of compensating for insufficient expression of regulatory microRNAs in humans and animals in a wide range of oncological diseases.https://www.mdpi.com/1467-3045/47/1/42miRNA expressioncancer treatmentstatistical complementarityplant miRNAs |
| spellingShingle | Maksym Zoziuk Vittorio Colizzi Pavlo Krysenko Maurizio Mattei Roberta Bernardini Fabio Massimo Zanzotto Stefano Marini Dmitri Koroliouk Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers Current Issues in Molecular Biology miRNA expression cancer treatment statistical complementarity plant miRNAs |
| title | Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers |
| title_full | Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers |
| title_fullStr | Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers |
| title_full_unstemmed | Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers |
| title_short | Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers |
| title_sort | plant mirnas for improved gene regulation in a wide range of human cancers |
| topic | miRNA expression cancer treatment statistical complementarity plant miRNAs |
| url | https://www.mdpi.com/1467-3045/47/1/42 |
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