Micellar Enhanced Three-Dimensional Excitation-Emission Matrix Fluorescence for Rapid Determination of Antihypertensives in Human Plasma with Aid of Second-Order Calibration Methods
A highly sensitive three-dimensional excitation-emission fluorescence method was proposed to determine antihypertensives including valsartan and amlodipine besylate in human plasma with the aid of second-order calibration methods based on parallel factor analysis (PARAFAC) and alternating trilinear...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2015/681320 |
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| author | Hai-Yan Fu He-Dong Li Chuang Ni Tian-Ming Yang Yao Fan Hao Zhang Ji Yang Lin Chen Yuan-Bin She |
| author_facet | Hai-Yan Fu He-Dong Li Chuang Ni Tian-Ming Yang Yao Fan Hao Zhang Ji Yang Lin Chen Yuan-Bin She |
| author_sort | Hai-Yan Fu |
| collection | DOAJ |
| description | A highly sensitive three-dimensional excitation-emission fluorescence method was proposed to determine antihypertensives including valsartan and amlodipine besylate in human plasma with the aid of second-order calibration methods based on parallel factor analysis (PARAFAC) and alternating trilinear decomposition (ATLD) algorithms. Antihypertensives with weak fluorescent can be transformed into a strong fluorescent property by changing microenvironment in samples using micellar enhanced surfactant. Both the adopted algorithms with second-order advantage can improve the resolution and directly attain antihypertensives concentration even in the presence of potential strong intrinsic fluorescence from human plasma. The satisfactory results can be achieved for valsartan and amlodipine besylate in complicated human plasma. Furthermore, some statistical parameters and figures of merit were evaluated to investigate the performance of the proposed method, and the accuracy and precision of the proposed method were also validated by the elliptical joint confidence region (EJCR) test and repeatability analysis of intraday and interday assay. The proposed method could not only light a new avenue to directly determine valsartan or amlodipine besylate in human plasma, but also hold great potential to be extended as a promising alternative for more practical applications in the determination of weak fluorescent drugs. |
| format | Article |
| id | doaj-art-a5d05e2a3e6f49be8a8ac8b5bbabcd7a |
| institution | Kabale University |
| issn | 2314-4920 2314-4939 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-a5d05e2a3e6f49be8a8ac8b5bbabcd7a2025-08-20T03:38:44ZengWileyJournal of Spectroscopy2314-49202314-49392015-01-01201510.1155/2015/681320681320Micellar Enhanced Three-Dimensional Excitation-Emission Matrix Fluorescence for Rapid Determination of Antihypertensives in Human Plasma with Aid of Second-Order Calibration MethodsHai-Yan Fu0He-Dong Li1Chuang Ni2Tian-Ming Yang3Yao Fan4Hao Zhang5Ji Yang6Lin Chen7Yuan-Bin She8Third Class Laboratory about Ethno-Medicine of State Administration of Traditional Chinese Medicine, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, ChinaThird Class Laboratory about Ethno-Medicine of State Administration of Traditional Chinese Medicine, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, ChinaThird Class Laboratory about Ethno-Medicine of State Administration of Traditional Chinese Medicine, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, ChinaThird Class Laboratory about Ethno-Medicine of State Administration of Traditional Chinese Medicine, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, ChinaThird Class Laboratory about Ethno-Medicine of State Administration of Traditional Chinese Medicine, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, ChinaThird Class Laboratory about Ethno-Medicine of State Administration of Traditional Chinese Medicine, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, ChinaThird Class Laboratory about Ethno-Medicine of State Administration of Traditional Chinese Medicine, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, ChinaThird Class Laboratory about Ethno-Medicine of State Administration of Traditional Chinese Medicine, College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, ChinaState Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, ChinaA highly sensitive three-dimensional excitation-emission fluorescence method was proposed to determine antihypertensives including valsartan and amlodipine besylate in human plasma with the aid of second-order calibration methods based on parallel factor analysis (PARAFAC) and alternating trilinear decomposition (ATLD) algorithms. Antihypertensives with weak fluorescent can be transformed into a strong fluorescent property by changing microenvironment in samples using micellar enhanced surfactant. Both the adopted algorithms with second-order advantage can improve the resolution and directly attain antihypertensives concentration even in the presence of potential strong intrinsic fluorescence from human plasma. The satisfactory results can be achieved for valsartan and amlodipine besylate in complicated human plasma. Furthermore, some statistical parameters and figures of merit were evaluated to investigate the performance of the proposed method, and the accuracy and precision of the proposed method were also validated by the elliptical joint confidence region (EJCR) test and repeatability analysis of intraday and interday assay. The proposed method could not only light a new avenue to directly determine valsartan or amlodipine besylate in human plasma, but also hold great potential to be extended as a promising alternative for more practical applications in the determination of weak fluorescent drugs.http://dx.doi.org/10.1155/2015/681320 |
| spellingShingle | Hai-Yan Fu He-Dong Li Chuang Ni Tian-Ming Yang Yao Fan Hao Zhang Ji Yang Lin Chen Yuan-Bin She Micellar Enhanced Three-Dimensional Excitation-Emission Matrix Fluorescence for Rapid Determination of Antihypertensives in Human Plasma with Aid of Second-Order Calibration Methods Journal of Spectroscopy |
| title | Micellar Enhanced Three-Dimensional Excitation-Emission Matrix Fluorescence for Rapid Determination of Antihypertensives in Human Plasma with Aid of Second-Order Calibration Methods |
| title_full | Micellar Enhanced Three-Dimensional Excitation-Emission Matrix Fluorescence for Rapid Determination of Antihypertensives in Human Plasma with Aid of Second-Order Calibration Methods |
| title_fullStr | Micellar Enhanced Three-Dimensional Excitation-Emission Matrix Fluorescence for Rapid Determination of Antihypertensives in Human Plasma with Aid of Second-Order Calibration Methods |
| title_full_unstemmed | Micellar Enhanced Three-Dimensional Excitation-Emission Matrix Fluorescence for Rapid Determination of Antihypertensives in Human Plasma with Aid of Second-Order Calibration Methods |
| title_short | Micellar Enhanced Three-Dimensional Excitation-Emission Matrix Fluorescence for Rapid Determination of Antihypertensives in Human Plasma with Aid of Second-Order Calibration Methods |
| title_sort | micellar enhanced three dimensional excitation emission matrix fluorescence for rapid determination of antihypertensives in human plasma with aid of second order calibration methods |
| url | http://dx.doi.org/10.1155/2015/681320 |
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