Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies

Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies

Hepatic encephalopathy, defined as neuropsychiatric dysfunction secondary to liver disease, is a frequent decompensating event in cirrhosis. Its clinical impact is highlighted by a notable increase in patient mortality rates and a concomitant reduction in overall quality of life. Systemically, liver...

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Bibliographic Details
Main Authors: Wouter Claeys, Anja Geerts, Lien Van Hoecke, Christophe Van Steenkiste, Roosmarijn E. Vandenbroucke
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-12-01
Series:Neural Regeneration Research
Subjects:
ammonia
astrocytes
cirrhosis
hepatic encephalopathy
microglia
neuroinflammation
osmotic stress
oxidative stress
systemic inflammation
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-00600
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