Unraveling the Engagement of Kinases to CRBN Through a Shared Structural Motif to Optimize PROTACs Efficacy

Unraveling the Engagement of Kinases to CRBN Through a Shared Structural Motif to Optimize PROTACs Efficacy

PROteolysis TArgeting Chimeras (PROTACs) offer a therapeutic modality for protein target engagement, exploiting the ubiquitin–proteasome system to achieve precise degradation of a protein of interest. Recent advancements in understanding the structural biology of the CRL4A E3 ligase complex, particu...

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Bibliographic Details
Main Authors: Serena Rosignoli, Sara Giordani, Maddalena Pacelli, Giulia Guarguaglini, Alessandro Paiardini
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Biomolecules
Subjects:
PROTACs
kinases
E3 ligases
G-loop
Online Access:https://www.mdpi.com/2218-273X/15/2/206
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