PD-1IR2 promotes tumor evasion via deregulating CD8+ T cell function

PD-1IR2 promotes tumor evasion via deregulating CD8+ T cell function

Background The programmed cell death 1 (PD-1) is an immune checkpoint that mediates immune evasion of tumors. Alternative splicing (AS) such as intron retention (IR) plays a crucial role in the immune-related gene processing and its function. However, it is not clear whether PDCD1 encoding PD-1 exis...

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Main Authors: Xiaodong Wang, Shan Gao, Xiaofeng Zhu, Hongbo Hu, Fang Guo, Shuwen Cheng, Chang Huang, Haojing Zang, Tongfeng Liu, Liqiang Duan, Xujie Zhao, Xuetong Wang, Chang Zhang, Facai Yang, Yinmin Gu
Format: Article
Language:English
Published: BMJ Publishing Group 2025-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/3/e010529.full
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