Comparison of GLP-1 Receptor Agonists, SGLT-2 Inhibitors, and DPP-4 Inhibitors as an Add-On Drug to Insulin Combined With Oral Hypoglycemic Drugs: Umbrella Review
Conclusions: The combination of GLP-1 RAs, DPP-4i, and SGLT-2i can effectively lower HbA1c and FPG in T2DM patients who have poor therapeutic effects on basic insulin combined with metformin/sulfonylureas, respectively. Compared to placebo, GLP-1 RAs can significantly reduce body weight and basic in...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2024/8145388 |
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| _version_ | 1832546213020303360 |
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| author | Sanbao Chai Yapin Niu Fengqi Liu Shanshan Wu Zhirong Yang Feng Sun |
| author_facet | Sanbao Chai Yapin Niu Fengqi Liu Shanshan Wu Zhirong Yang Feng Sun |
| author_sort | Sanbao Chai |
| collection | DOAJ |
| description | Conclusions: The combination of GLP-1 RAs, DPP-4i, and SGLT-2i can effectively lower HbA1c and FPG in T2DM patients who have poor therapeutic effects on basic insulin combined with metformin/sulfonylureas, respectively. Compared to placebo, GLP-1 RAs can significantly reduce body weight and basic insulin dosage, while DPP-4i and SGLT-2i have a lower risk of hypoglycemia. |
| format | Article |
| id | doaj-art-a59fa84116bf46e5afce9ee8f094b123 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-a59fa84116bf46e5afce9ee8f094b1232025-02-03T07:23:36ZengWileyJournal of Diabetes Research2314-67532024-01-01202410.1155/2024/8145388Comparison of GLP-1 Receptor Agonists, SGLT-2 Inhibitors, and DPP-4 Inhibitors as an Add-On Drug to Insulin Combined With Oral Hypoglycemic Drugs: Umbrella ReviewSanbao Chai0Yapin Niu1Fengqi Liu2Shanshan Wu3Zhirong Yang4Feng Sun5Department of Endocrinology and MetabolismDepartment of Epidemiology and BiostatisticsDepartment of Epidemiology and BiostatisticsNational Clinical Research Center of Digestive DiseasesShenzhen Institute of Advanced TechnologyDepartment of Epidemiology and BiostatisticsConclusions: The combination of GLP-1 RAs, DPP-4i, and SGLT-2i can effectively lower HbA1c and FPG in T2DM patients who have poor therapeutic effects on basic insulin combined with metformin/sulfonylureas, respectively. Compared to placebo, GLP-1 RAs can significantly reduce body weight and basic insulin dosage, while DPP-4i and SGLT-2i have a lower risk of hypoglycemia.http://dx.doi.org/10.1155/2024/8145388 |
| spellingShingle | Sanbao Chai Yapin Niu Fengqi Liu Shanshan Wu Zhirong Yang Feng Sun Comparison of GLP-1 Receptor Agonists, SGLT-2 Inhibitors, and DPP-4 Inhibitors as an Add-On Drug to Insulin Combined With Oral Hypoglycemic Drugs: Umbrella Review Journal of Diabetes Research |
| title | Comparison of GLP-1 Receptor Agonists, SGLT-2 Inhibitors, and DPP-4 Inhibitors as an Add-On Drug to Insulin Combined With Oral Hypoglycemic Drugs: Umbrella Review |
| title_full | Comparison of GLP-1 Receptor Agonists, SGLT-2 Inhibitors, and DPP-4 Inhibitors as an Add-On Drug to Insulin Combined With Oral Hypoglycemic Drugs: Umbrella Review |
| title_fullStr | Comparison of GLP-1 Receptor Agonists, SGLT-2 Inhibitors, and DPP-4 Inhibitors as an Add-On Drug to Insulin Combined With Oral Hypoglycemic Drugs: Umbrella Review |
| title_full_unstemmed | Comparison of GLP-1 Receptor Agonists, SGLT-2 Inhibitors, and DPP-4 Inhibitors as an Add-On Drug to Insulin Combined With Oral Hypoglycemic Drugs: Umbrella Review |
| title_short | Comparison of GLP-1 Receptor Agonists, SGLT-2 Inhibitors, and DPP-4 Inhibitors as an Add-On Drug to Insulin Combined With Oral Hypoglycemic Drugs: Umbrella Review |
| title_sort | comparison of glp 1 receptor agonists sglt 2 inhibitors and dpp 4 inhibitors as an add on drug to insulin combined with oral hypoglycemic drugs umbrella review |
| url | http://dx.doi.org/10.1155/2024/8145388 |
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