The effect of low donor-to-recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donors
Background Dual kidney transplantation (DKT) from small pediatric donors, either en-bloc or split dual kidney transplantation, contributes to mitigating organ scarcity. This study investigates the prognosis of DKT from pediatric deceased donors, and influencing factors.Method A retrospective study i...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2454968 |
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| author | Mingchuan Huang Shenghui Wu Pengfei Gao Li Zhou Qian Fu Chenglin Wu Huanxi Zhang Yitao Zheng Xiaojun Su Wenrui Wu Jinghong Tan Qiang Zhang Pei Xia Zhe Xu Longshan Liu Jun Li Changxi Wang |
| author_facet | Mingchuan Huang Shenghui Wu Pengfei Gao Li Zhou Qian Fu Chenglin Wu Huanxi Zhang Yitao Zheng Xiaojun Su Wenrui Wu Jinghong Tan Qiang Zhang Pei Xia Zhe Xu Longshan Liu Jun Li Changxi Wang |
| author_sort | Mingchuan Huang |
| collection | DOAJ |
| description | Background Dual kidney transplantation (DKT) from small pediatric donors, either en-bloc or split dual kidney transplantation, contributes to mitigating organ scarcity. This study investigates the prognosis of DKT from pediatric deceased donors, and influencing factors.Method A retrospective study included recipients who underwent DKT from pediatric donors between 2012 and 2022. Recipients were categorized into low mismatch (BWLM, n = 30) and high mismatch (BWHM, n = 10) groups based on donor-recipient weight ratio of 1:10. Outcome encompassed recipient and graft survival, renal function, and adverse events.Result Forty recipients were included. The average follow-up period was 54.6 months. The 1, 3, and 5-year patient survival were 97.4%, with no significant differences between en-bloc and split dual kidney transplantation or between BWLM and BWHM groups. The graft survival at 1, 3, and 5 years were 89.9%, the graft survival of BWHM group was lower than BWLM group (70% vs 96.7%, p = 0.039). The average eGFR at 1, 3, and 5 years postoperatively were (78.93 ± 25.23), (83.82 ± 32.4), and (85.92 ± 37.08) mL/min/1.73 m2, respectively. The BWHM group also experienced higher rates of graft-related surgical complications (p = 0.006) and urinary tract surgical complications (p = 0.042).Conclusion DKT from pediatric donors yields favorable outcomes, with similar graft survival and complication rates across surgical subgroups. However, significant donor-recipient weight mismatch, particularly when the ratio is less than 1:10, may contribute to increased surgical complications and poorer graft survival. Efforts to minimize extreme weight mismatch are recommended to optimize outcomes. |
| format | Article |
| id | doaj-art-a577037a60684c18a5675ae100f95243 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-a577037a60684c18a5675ae100f952432025-01-23T01:09:39ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2454968The effect of low donor-to-recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donorsMingchuan Huang0Shenghui Wu1Pengfei Gao2Li Zhou3Qian Fu4Chenglin Wu5Huanxi Zhang6Yitao Zheng7Xiaojun Su8Wenrui Wu9Jinghong Tan10Qiang Zhang11Pei Xia12Zhe Xu13Longshan Liu14Jun Li15Changxi Wang16Department of Pediatric Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaFirst Affiliated Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Pediatric Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Pediatric Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaOrgan Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaOrgan Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaOrgan Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaKidney Transplantation Department, The Third People’s Hospital of Shenzhen, Shenzhen, ChinaOrgan Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaOrgan Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaOrgan Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaOrgan Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Pathology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Pediatric Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaOrgan Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaOrgan Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaOrgan Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaBackground Dual kidney transplantation (DKT) from small pediatric donors, either en-bloc or split dual kidney transplantation, contributes to mitigating organ scarcity. This study investigates the prognosis of DKT from pediatric deceased donors, and influencing factors.Method A retrospective study included recipients who underwent DKT from pediatric donors between 2012 and 2022. Recipients were categorized into low mismatch (BWLM, n = 30) and high mismatch (BWHM, n = 10) groups based on donor-recipient weight ratio of 1:10. Outcome encompassed recipient and graft survival, renal function, and adverse events.Result Forty recipients were included. The average follow-up period was 54.6 months. The 1, 3, and 5-year patient survival were 97.4%, with no significant differences between en-bloc and split dual kidney transplantation or between BWLM and BWHM groups. The graft survival at 1, 3, and 5 years were 89.9%, the graft survival of BWHM group was lower than BWLM group (70% vs 96.7%, p = 0.039). The average eGFR at 1, 3, and 5 years postoperatively were (78.93 ± 25.23), (83.82 ± 32.4), and (85.92 ± 37.08) mL/min/1.73 m2, respectively. The BWHM group also experienced higher rates of graft-related surgical complications (p = 0.006) and urinary tract surgical complications (p = 0.042).Conclusion DKT from pediatric donors yields favorable outcomes, with similar graft survival and complication rates across surgical subgroups. However, significant donor-recipient weight mismatch, particularly when the ratio is less than 1:10, may contribute to increased surgical complications and poorer graft survival. Efforts to minimize extreme weight mismatch are recommended to optimize outcomes.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2454968Dual kidney transplantpediatric donorbody weight ratiosurvival analysissurgical procedure |
| spellingShingle | Mingchuan Huang Shenghui Wu Pengfei Gao Li Zhou Qian Fu Chenglin Wu Huanxi Zhang Yitao Zheng Xiaojun Su Wenrui Wu Jinghong Tan Qiang Zhang Pei Xia Zhe Xu Longshan Liu Jun Li Changxi Wang The effect of low donor-to-recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donors Renal Failure Dual kidney transplant pediatric donor body weight ratio survival analysis surgical procedure |
| title | The effect of low donor-to-recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donors |
| title_full | The effect of low donor-to-recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donors |
| title_fullStr | The effect of low donor-to-recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donors |
| title_full_unstemmed | The effect of low donor-to-recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donors |
| title_short | The effect of low donor-to-recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donors |
| title_sort | effect of low donor to recipient body weight ratio on graft survival after dual kidney transplantation from pediatric deceased donors |
| topic | Dual kidney transplant pediatric donor body weight ratio survival analysis surgical procedure |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2454968 |
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