Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets
Hepatic macrophages account for the largest non-parenchymal cell population in the liver. Recent studies have found that hepatic macrophages have different functions in different stages of experimental liver fibrosis. Some studies found that there are different types of hepatic macrophages in the li...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2016-05-01
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| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/3/1/e000079.full |
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| _version_ | 1832574244166303744 |
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| author | Hai Li Hong You Jidong Jia Xu Fan |
| author_facet | Hai Li Hong You Jidong Jia Xu Fan |
| author_sort | Hai Li |
| collection | DOAJ |
| description | Hepatic macrophages account for the largest non-parenchymal cell population in the liver. Recent studies have found that hepatic macrophages have different functions in different stages of experimental liver fibrosis. Some studies found that there are different types of hepatic macrophages in the liver, although others have suggested that hepatic macrophages could switch to different phenotypes in different environments. Many studies demonstrated that while hepatic macrophages promoted fibrosis through the recruitment of proinflammatory immune cells, and the secretion of proinflammatory cytokines and chemokines in the early stages, these also promoted the resolution of hepatic fibrosis through the secretion of matrix metalloproteinases in the late stages. This article will review the current role played by hepatic macrophages in liver fibrosis and the potential therapeutic targets that modulate hepatic macrophages. |
| format | Article |
| id | doaj-art-a57356755b9c4f3e8014130dc4457af4 |
| institution | Kabale University |
| issn | 2054-4774 |
| language | English |
| publishDate | 2016-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj-art-a57356755b9c4f3e8014130dc4457af42025-02-02T00:10:10ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742016-05-013110.1136/bmjgast-2016-000079Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targetsHai Li0Hong You1Jidong Jia2Xu Fan3associate professor5 Medical Image Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China4 Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China3State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, People`s Republic of ChinaHepatic macrophages account for the largest non-parenchymal cell population in the liver. Recent studies have found that hepatic macrophages have different functions in different stages of experimental liver fibrosis. Some studies found that there are different types of hepatic macrophages in the liver, although others have suggested that hepatic macrophages could switch to different phenotypes in different environments. Many studies demonstrated that while hepatic macrophages promoted fibrosis through the recruitment of proinflammatory immune cells, and the secretion of proinflammatory cytokines and chemokines in the early stages, these also promoted the resolution of hepatic fibrosis through the secretion of matrix metalloproteinases in the late stages. This article will review the current role played by hepatic macrophages in liver fibrosis and the potential therapeutic targets that modulate hepatic macrophages.https://bmjopengastro.bmj.com/content/3/1/e000079.full |
| spellingShingle | Hai Li Hong You Jidong Jia Xu Fan Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets BMJ Open Gastroenterology |
| title | Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets |
| title_full | Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets |
| title_fullStr | Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets |
| title_full_unstemmed | Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets |
| title_short | Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets |
| title_sort | hepatic macrophages in liver fibrosis pathogenesis and potential therapeutic targets |
| url | https://bmjopengastro.bmj.com/content/3/1/e000079.full |
| work_keys_str_mv | AT haili hepaticmacrophagesinliverfibrosispathogenesisandpotentialtherapeutictargets AT hongyou hepaticmacrophagesinliverfibrosispathogenesisandpotentialtherapeutictargets AT jidongjia hepaticmacrophagesinliverfibrosispathogenesisandpotentialtherapeutictargets AT xufan hepaticmacrophagesinliverfibrosispathogenesisandpotentialtherapeutictargets |