Bidirectional roles of nanoenzymes in enhancing GPC3-CAR T cell infiltration and cancer immunotherapy

Bidirectional roles of nanoenzymes in enhancing GPC3-CAR T cell infiltration and cancer immunotherapy

Abstract Background Vascular abnormalities and hypoxia in solid tumors limit the efficacy of chimeric antigen receptor (CAR) T-cell therapy. This study proposes a biomimic nanoenzyme, Lenv@BSA-PtNPs, combining platinum nanoparticles (PtNPs) and lenvatinib, to address these challenges in a hepatocell...

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Bibliographic Details
Main Authors: Yu Xu, Jianping Liao, Jiahong Wang, Yuan Gao, Yuan Wu, Meiqin Gao, Wenwen Liu, Da Zhang, Wenmin Zhang, Aimin Huang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Nanoenzyme
Vascular normalization
Hypoxia
GPC3-CAR T cells immunity
Online Access:https://doi.org/10.1186/s12967-025-06636-7
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