Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis
In both autoimmune liver disease and chronic viral hepatitis, the injury results from an immune-mediated cytotoxic T cell response to liver cells. As such, it is not surprising that CD4+ regulatory T cells, a key regulatory population of T cells able to curb immune responses, could be involved in bo...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/479703 |
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| author | Pascal Lapierre Alain Lamarre |
| author_facet | Pascal Lapierre Alain Lamarre |
| author_sort | Pascal Lapierre |
| collection | DOAJ |
| description | In both autoimmune liver disease and chronic viral hepatitis, the injury results from an immune-mediated cytotoxic T cell response to liver cells. As such, it is not surprising that CD4+ regulatory T cells, a key regulatory population of T cells able to curb immune responses, could be involved in both autoimmune hepatitis and chronic viral hepatitis. The liver can induce the conversion of naïve CD4+ T cells to CD4+ regulatory T cells and induce tolerance to locally expressed antigens. This tolerance mechanism is carefully regulated in physiological conditions but any imbalance could be pathological. An overly tolerant immune response can lead to chronic infections while an overreactive and unbridled immune response can lead to autoimmune hepatitis. With the recent advent of monoclonal antibodies able to target regulatory T cells (daclizumab) and improve immune responses and several ongoing clinical trials analysing the impact of regulatory T cell infusion on autoimmune liver disease or liver transplant tolerance, modulation of immunological tolerance through CD4+ regulatory T cells could be a key element of future immunotherapies for several liver diseases allowing restoring the balance between proper immune responses and tolerance. |
| format | Article |
| id | doaj-art-a566dc95e598441b93aa0e7f4f549538 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-a566dc95e598441b93aa0e7f4f5495382025-02-03T01:10:21ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/479703479703Regulatory T Cells in Autoimmune and Viral Chronic HepatitisPascal Lapierre0Alain Lamarre1Laboratoire d’Immunovirologie, Institut National de la Recherche Scientifique, INRS-Institut Armand-Frappier, Laval, QC, H7V 1B7, CanadaLaboratoire d’Immunovirologie, Institut National de la Recherche Scientifique, INRS-Institut Armand-Frappier, Laval, QC, H7V 1B7, CanadaIn both autoimmune liver disease and chronic viral hepatitis, the injury results from an immune-mediated cytotoxic T cell response to liver cells. As such, it is not surprising that CD4+ regulatory T cells, a key regulatory population of T cells able to curb immune responses, could be involved in both autoimmune hepatitis and chronic viral hepatitis. The liver can induce the conversion of naïve CD4+ T cells to CD4+ regulatory T cells and induce tolerance to locally expressed antigens. This tolerance mechanism is carefully regulated in physiological conditions but any imbalance could be pathological. An overly tolerant immune response can lead to chronic infections while an overreactive and unbridled immune response can lead to autoimmune hepatitis. With the recent advent of monoclonal antibodies able to target regulatory T cells (daclizumab) and improve immune responses and several ongoing clinical trials analysing the impact of regulatory T cell infusion on autoimmune liver disease or liver transplant tolerance, modulation of immunological tolerance through CD4+ regulatory T cells could be a key element of future immunotherapies for several liver diseases allowing restoring the balance between proper immune responses and tolerance.http://dx.doi.org/10.1155/2015/479703 |
| spellingShingle | Pascal Lapierre Alain Lamarre Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis Journal of Immunology Research |
| title | Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis |
| title_full | Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis |
| title_fullStr | Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis |
| title_full_unstemmed | Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis |
| title_short | Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis |
| title_sort | regulatory t cells in autoimmune and viral chronic hepatitis |
| url | http://dx.doi.org/10.1155/2015/479703 |
| work_keys_str_mv | AT pascallapierre regulatorytcellsinautoimmuneandviralchronichepatitis AT alainlamarre regulatorytcellsinautoimmuneandviralchronichepatitis |