Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional Study
Background. The aim of this study was to evaluate the prevalence of vitamin D deficiency in pregnant women to investigate the relationship between vitamin D level and thyroid function. Methods. In this cross-sectional descriptive study, a total number of 66 patients during the three trimesters of pr...
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| Format: | Article |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/6295775 |
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| author | Salma Ahi Mohsen Adelpour Iman Fereydooni Naser Hatami |
| author_facet | Salma Ahi Mohsen Adelpour Iman Fereydooni Naser Hatami |
| author_sort | Salma Ahi |
| collection | DOAJ |
| description | Background. The aim of this study was to evaluate the prevalence of vitamin D deficiency in pregnant women to investigate the relationship between vitamin D level and thyroid function. Methods. In this cross-sectional descriptive study, a total number of 66 patients during the three trimesters of pregnancy were investigated; 22 pregnant women were studied in each trimester of pregnancy. We evaluated thyroid function tests and thyroid autoantibodies (TPOAb and TGAb), as well as the serum level of 25OHD, to determine the relationship between vitamin D level and autoimmune or non-autoimmune thyroid disease in pregnancy. Results. Pearson’s correlation in all subjects showed that vitamin D levels did not have a significant relationship with maternal age. Only in the third trimester, there was a significant difference in maternal age based on their vitamin D status. There was no significant difference between the trimesters of pregnancy and vitamin D status (P>0.05). Also, there were no significant differences between serum levels of vitamin D within three trimesters. Examination of thyroid function tests during pregnancy in relation to vitamin D showed that there was no significant Spearman’s correlation between thyroid function status and serum vitamin D level (P>0.05). There was no significant difference in the mean level of serum 25OH vitamin D in each subgroup of thyroid status (P>0.05). Regarding the pregnancy outcomes, two newborns were admitted to NICU, meconium aspiration was in one case, and IUFD in another case led to pregnancy termination. These four cases were related to the maternal history of hypothyroidism. Conclusion. There was no significant relationship between vitamin D and pregnancy trimester. The serum level of vitamin D had no particular effect on the outcome of pregnancy and the thyroid gland function. |
| format | Article |
| id | doaj-art-a54076d5406343b8a1485b30f03d1e6a |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a54076d5406343b8a1485b30f03d1e6a2025-02-03T01:10:37ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/6295775Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional StudySalma Ahi0Mohsen Adelpour1Iman Fereydooni2Naser Hatami3Research Center for Noncommunicable DiseasesResearch Center for Noncommunicable DiseasesStudent Research CommitteeStudent Research CommitteeBackground. The aim of this study was to evaluate the prevalence of vitamin D deficiency in pregnant women to investigate the relationship between vitamin D level and thyroid function. Methods. In this cross-sectional descriptive study, a total number of 66 patients during the three trimesters of pregnancy were investigated; 22 pregnant women were studied in each trimester of pregnancy. We evaluated thyroid function tests and thyroid autoantibodies (TPOAb and TGAb), as well as the serum level of 25OHD, to determine the relationship between vitamin D level and autoimmune or non-autoimmune thyroid disease in pregnancy. Results. Pearson’s correlation in all subjects showed that vitamin D levels did not have a significant relationship with maternal age. Only in the third trimester, there was a significant difference in maternal age based on their vitamin D status. There was no significant difference between the trimesters of pregnancy and vitamin D status (P>0.05). Also, there were no significant differences between serum levels of vitamin D within three trimesters. Examination of thyroid function tests during pregnancy in relation to vitamin D showed that there was no significant Spearman’s correlation between thyroid function status and serum vitamin D level (P>0.05). There was no significant difference in the mean level of serum 25OH vitamin D in each subgroup of thyroid status (P>0.05). Regarding the pregnancy outcomes, two newborns were admitted to NICU, meconium aspiration was in one case, and IUFD in another case led to pregnancy termination. These four cases were related to the maternal history of hypothyroidism. Conclusion. There was no significant relationship between vitamin D and pregnancy trimester. The serum level of vitamin D had no particular effect on the outcome of pregnancy and the thyroid gland function.http://dx.doi.org/10.1155/2022/6295775 |
| spellingShingle | Salma Ahi Mohsen Adelpour Iman Fereydooni Naser Hatami Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional Study International Journal of Endocrinology |
| title | Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional Study |
| title_full | Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional Study |
| title_fullStr | Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional Study |
| title_full_unstemmed | Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional Study |
| title_short | Correlation between Maternal Vitamin D and Thyroid Function in Pregnancy with Maternal and Neonatal Outcomes: A Cross-Sectional Study |
| title_sort | correlation between maternal vitamin d and thyroid function in pregnancy with maternal and neonatal outcomes a cross sectional study |
| url | http://dx.doi.org/10.1155/2022/6295775 |
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