Myocarditis following mRNA COVID‐19 vaccination: call for endomyocardial biopsy
Abstract Acute myocarditis following mRNA COVID‐19 vaccination was reported by the European Medicine Agency safety committee as a rare adverse event. We present a case series of three young male patients with suspected acute myocarditis following BNT162b2 mRNA COVID‐19 vaccination including results...
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.13791 |
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| author | Daniel Kiblboeck Karin Klingel Martin Genger Selina Traxler Nathalie Braunsteiner Clemens Steinwender Joerg Kellermair |
| author_facet | Daniel Kiblboeck Karin Klingel Martin Genger Selina Traxler Nathalie Braunsteiner Clemens Steinwender Joerg Kellermair |
| author_sort | Daniel Kiblboeck |
| collection | DOAJ |
| description | Abstract Acute myocarditis following mRNA COVID‐19 vaccination was reported by the European Medicine Agency safety committee as a rare adverse event. We present a case series of three young male patients with suspected acute myocarditis following BNT162b2 mRNA COVID‐19 vaccination including results of endomyocardial biopsies (EMB). Additionally, we analysed EMB of another 21 patients with clinically suspected acute myocarditis following vaccination to determine the pathohistological pattern. Overall, EMB revealed acute lymphocytic myocarditis in 5 (20.8%), chronic lymphocytic myocarditis in 6 (25%), cardiac sarcoidosis in 1 (4.2%), healed myocarditis in 6 (25%), and other diagnoses with cardiac damage of unclear aetiology in 6 (25%) cases. Our findings support the necessity of EMB in patients with suspected acute myocarditis following mRNA COVID‐19 vaccination presenting with reduced EF to establish a correct and definite diagnosis. Concerns of these rare severe adverse events after COVID‐19 immunization should not undermine its value for the global community. |
| format | Article |
| id | doaj-art-a5332034f82344d182e644e1e1e083bf |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-a5332034f82344d182e644e1e1e083bf2025-02-05T05:22:10ZengWileyESC Heart Failure2055-58222022-06-01931996200210.1002/ehf2.13791Myocarditis following mRNA COVID‐19 vaccination: call for endomyocardial biopsyDaniel Kiblboeck0Karin Klingel1Martin Genger2Selina Traxler3Nathalie Braunsteiner4Clemens Steinwender5Joerg Kellermair6Department of Cardiology, Kepler University Hospital, Med Campus III, Medical Faculty Johannes Kepler University Linz AustriaCardiopathology, Institute for Pathology and Neuropathology University Hospital Tübingen Tübingen GermanyDepartment of Cardiology, Nephrology and Intensive Care General Hospital Steyr Steyr AustriaCardiopathology, Institute for Pathology and Neuropathology University Hospital Tübingen Tübingen GermanyDepartment of Cardiology, Nephrology and Intensive Care General Hospital Steyr Steyr AustriaDepartment of Cardiology, Kepler University Hospital, Med Campus III, Medical Faculty Johannes Kepler University Linz AustriaDepartment of Cardiology, Kepler University Hospital, Med Campus III, Medical Faculty Johannes Kepler University Linz AustriaAbstract Acute myocarditis following mRNA COVID‐19 vaccination was reported by the European Medicine Agency safety committee as a rare adverse event. We present a case series of three young male patients with suspected acute myocarditis following BNT162b2 mRNA COVID‐19 vaccination including results of endomyocardial biopsies (EMB). Additionally, we analysed EMB of another 21 patients with clinically suspected acute myocarditis following vaccination to determine the pathohistological pattern. Overall, EMB revealed acute lymphocytic myocarditis in 5 (20.8%), chronic lymphocytic myocarditis in 6 (25%), cardiac sarcoidosis in 1 (4.2%), healed myocarditis in 6 (25%), and other diagnoses with cardiac damage of unclear aetiology in 6 (25%) cases. Our findings support the necessity of EMB in patients with suspected acute myocarditis following mRNA COVID‐19 vaccination presenting with reduced EF to establish a correct and definite diagnosis. Concerns of these rare severe adverse events after COVID‐19 immunization should not undermine its value for the global community.https://doi.org/10.1002/ehf2.13791MyocarditisCOVID‐19VaccinationEndomyocardial biopsy |
| spellingShingle | Daniel Kiblboeck Karin Klingel Martin Genger Selina Traxler Nathalie Braunsteiner Clemens Steinwender Joerg Kellermair Myocarditis following mRNA COVID‐19 vaccination: call for endomyocardial biopsy ESC Heart Failure Myocarditis COVID‐19 Vaccination Endomyocardial biopsy |
| title | Myocarditis following mRNA COVID‐19 vaccination: call for endomyocardial biopsy |
| title_full | Myocarditis following mRNA COVID‐19 vaccination: call for endomyocardial biopsy |
| title_fullStr | Myocarditis following mRNA COVID‐19 vaccination: call for endomyocardial biopsy |
| title_full_unstemmed | Myocarditis following mRNA COVID‐19 vaccination: call for endomyocardial biopsy |
| title_short | Myocarditis following mRNA COVID‐19 vaccination: call for endomyocardial biopsy |
| title_sort | myocarditis following mrna covid 19 vaccination call for endomyocardial biopsy |
| topic | Myocarditis COVID‐19 Vaccination Endomyocardial biopsy |
| url | https://doi.org/10.1002/ehf2.13791 |
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