Maternal F1 antibodies and cytokines in mother-neonate dog pairs in the Marmota himalayana plague focus
In this study, we investigated the F1 antibody against Yersinia pestis in the sera of mother-neonate shepherd dog pairs in the Marmota himalayana plague focus of the Altun-Qilian Mountains, Qinghai-Tibetan Plateau, China. Seropositive shepherd dogs lived in plague-endemic regions, where marmots were...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025007169 |
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| author | Deming Tang Asaiti Bukai Shuai Qin Ran Duan Dongyue Lyu Zhaokai He Xiaojin Zheng Weiwei Wu Junrong Liang Haifu Qu Aidai Bieke Peng Zhang Dan Zhang Haonan Han Qun Duan Huaiqi Jing Xin Wang |
| author_facet | Deming Tang Asaiti Bukai Shuai Qin Ran Duan Dongyue Lyu Zhaokai He Xiaojin Zheng Weiwei Wu Junrong Liang Haifu Qu Aidai Bieke Peng Zhang Dan Zhang Haonan Han Qun Duan Huaiqi Jing Xin Wang |
| author_sort | Deming Tang |
| collection | DOAJ |
| description | In this study, we investigated the F1 antibody against Yersinia pestis in the sera of mother-neonate shepherd dog pairs in the Marmota himalayana plague focus of the Altun-Qilian Mountains, Qinghai-Tibetan Plateau, China. Seropositive shepherd dogs lived in plague-endemic regions, where marmots were infected with Y. pestis, whereas seronegative dogs lived in non-endemic regions. The neonatal F1 antibody titers positively correlated with the maternal titers within 3 months after birth, and the neonatal titers were similar to or slightly lower than the maternal titers. In the absence of reinfection, antibodies in the neonates were obtained from their mothers; titers decreased with age and disappeared after 3 months. Mean tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-2, IL-10, and nerve growth factor (NGF)-β were higher in the mothers than in neonates. Maternal TNF-α, IL-10, vascular endothelial growth factor (VEGF)-A, and NGF-β and neonatal monocyte chemoattractant factor (MCP)-1 and VEGF-A were positively correlated with F1 antibody titers. Our results reveal continuing vertical transmission of F1 antibodies between mother dogs and their offspring and cytokine signatures under plague. |
| format | Article |
| id | doaj-art-a53301cb8afb4c7485546f221fb546d6 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-a53301cb8afb4c7485546f221fb546d62025-02-05T04:32:18ZengElsevierHeliyon2405-84402025-02-01113e42336Maternal F1 antibodies and cytokines in mother-neonate dog pairs in the Marmota himalayana plague focusDeming Tang0Asaiti Bukai1Shuai Qin2Ran Duan3Dongyue Lyu4Zhaokai He5Xiaojin Zheng6Weiwei Wu7Junrong Liang8Haifu Qu9Aidai Bieke10Peng Zhang11Dan Zhang12Haonan Han13Qun Duan14Huaiqi Jing15Xin Wang16National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Dongcheng Center for Disease Control and Prevention, Beijing, ChinaAkesai Kazak Autonomous County Center for Disease Control and Prevention, Jiuquan, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaAkesai Kazak Autonomous County Center for Disease Control and Prevention, Jiuquan, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaAkesai Kazak Autonomous County Center for Disease Control and Prevention, Jiuquan, ChinaAkesai Kazak Autonomous County Center for Disease Control and Prevention, Jiuquan, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaNational Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Corresponding author.In this study, we investigated the F1 antibody against Yersinia pestis in the sera of mother-neonate shepherd dog pairs in the Marmota himalayana plague focus of the Altun-Qilian Mountains, Qinghai-Tibetan Plateau, China. Seropositive shepherd dogs lived in plague-endemic regions, where marmots were infected with Y. pestis, whereas seronegative dogs lived in non-endemic regions. The neonatal F1 antibody titers positively correlated with the maternal titers within 3 months after birth, and the neonatal titers were similar to or slightly lower than the maternal titers. In the absence of reinfection, antibodies in the neonates were obtained from their mothers; titers decreased with age and disappeared after 3 months. Mean tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-2, IL-10, and nerve growth factor (NGF)-β were higher in the mothers than in neonates. Maternal TNF-α, IL-10, vascular endothelial growth factor (VEGF)-A, and NGF-β and neonatal monocyte chemoattractant factor (MCP)-1 and VEGF-A were positively correlated with F1 antibody titers. Our results reveal continuing vertical transmission of F1 antibodies between mother dogs and their offspring and cytokine signatures under plague.http://www.sciencedirect.com/science/article/pii/S2405844025007169PlagueDogF1 antibodyCytokinesMother-to-child transmission |
| spellingShingle | Deming Tang Asaiti Bukai Shuai Qin Ran Duan Dongyue Lyu Zhaokai He Xiaojin Zheng Weiwei Wu Junrong Liang Haifu Qu Aidai Bieke Peng Zhang Dan Zhang Haonan Han Qun Duan Huaiqi Jing Xin Wang Maternal F1 antibodies and cytokines in mother-neonate dog pairs in the Marmota himalayana plague focus Heliyon Plague Dog F1 antibody Cytokines Mother-to-child transmission |
| title | Maternal F1 antibodies and cytokines in mother-neonate dog pairs in the Marmota himalayana plague focus |
| title_full | Maternal F1 antibodies and cytokines in mother-neonate dog pairs in the Marmota himalayana plague focus |
| title_fullStr | Maternal F1 antibodies and cytokines in mother-neonate dog pairs in the Marmota himalayana plague focus |
| title_full_unstemmed | Maternal F1 antibodies and cytokines in mother-neonate dog pairs in the Marmota himalayana plague focus |
| title_short | Maternal F1 antibodies and cytokines in mother-neonate dog pairs in the Marmota himalayana plague focus |
| title_sort | maternal f1 antibodies and cytokines in mother neonate dog pairs in the marmota himalayana plague focus |
| topic | Plague Dog F1 antibody Cytokines Mother-to-child transmission |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025007169 |
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