Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis
THE aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained elevated at 48 h. Neutralization of CCL6 significantly inhibited the macrophage infiltration (34-48%...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09629350400014172 |
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| author | Andrew M. LaFleur Nicholas W. Lukacs Steven L. Kunkel Akihiro Matsukawa |
| author_facet | Andrew M. LaFleur Nicholas W. Lukacs Steven L. Kunkel Akihiro Matsukawa |
| author_sort | Andrew M. LaFleur |
| collection | DOAJ |
| description | THE aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained elevated at 48 h. Neutralization of CCL6 significantly inhibited the macrophage infiltration (34-48% reduction), but not other cell types, without decreasing the other CC chemokines known to attract monocytes/macrophages. CCL6 was expressed in peripheral eosinophils and elicited macrophages, but not in elicited neutrophils. Peritoneal CCL6 level was not decreased in granulocyte-depleted mice where eosinophil influx was significantly impaired. Thus, CCL6 appears to contribute to the macrophage infiltration that is independent of other CC chemokines. Eosinophils pre-store CCL6, but do not release CCL6 in the peritoneum in this model of inflammation. |
| format | Article |
| id | doaj-art-a51a91526f674ea7bcadd3cc213a9c75 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a51a91526f674ea7bcadd3cc213a9c752025-02-03T01:33:05ZengWileyMediators of Inflammation0962-93511466-18612004-01-01135-634935510.1080/09629350400014172Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitisAndrew M. LaFleur0Nicholas W. Lukacs1Steven L. Kunkel2Akihiro Matsukawa3Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USADepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USADepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USADepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USATHE aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained elevated at 48 h. Neutralization of CCL6 significantly inhibited the macrophage infiltration (34-48% reduction), but not other cell types, without decreasing the other CC chemokines known to attract monocytes/macrophages. CCL6 was expressed in peripheral eosinophils and elicited macrophages, but not in elicited neutrophils. Peritoneal CCL6 level was not decreased in granulocyte-depleted mice where eosinophil influx was significantly impaired. Thus, CCL6 appears to contribute to the macrophage infiltration that is independent of other CC chemokines. Eosinophils pre-store CCL6, but do not release CCL6 in the peritoneum in this model of inflammation.http://dx.doi.org/10.1080/09629350400014172Acute inflammationCC chemokinesEosinophilsMonocytes/macrophagesNeutrophils. |
| spellingShingle | Andrew M. LaFleur Nicholas W. Lukacs Steven L. Kunkel Akihiro Matsukawa Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis Mediators of Inflammation Acute inflammation CC chemokines Eosinophils Monocytes/macrophages Neutrophils. |
| title | Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis |
| title_full | Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis |
| title_fullStr | Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis |
| title_full_unstemmed | Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis |
| title_short | Role of CC chemokine CCL6/C10 as a monocyte chemoattractant in a murine acute peritonitis |
| title_sort | role of cc chemokine ccl6 c10 as a monocyte chemoattractant in a murine acute peritonitis |
| topic | Acute inflammation CC chemokines Eosinophils Monocytes/macrophages Neutrophils. |
| url | http://dx.doi.org/10.1080/09629350400014172 |
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