Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.

The COVID-19 pandemic has been driven by SARS-CoV-2 variants with enhanced transmission and immune escape. Apart from extensive evolution in the Spike protein, non-Spike mutations are accumulating across the entire viral genome and their functional impact is not well understood. To address the contr...

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Main Authors: Taha Y Taha, Shahrzad Ezzatpour, Jennifer M Hayashi, Chengjin Ye, Francisco J Zapatero-Belinchón, Julia A Rosecrans, Gabriella R Kimmerly, Irene P Chen, Keith Walcott, Anna Kurianowicz, Danielle M Jorgens, Natalie R Chaplin, Annette Choi, David W Buchholz, Julie Sahler, Zachary T Hilt, Brian Imbiakha, Cecilia Vagi-Szmola, Mauricio Montano, Erica Stevenson, Martin Gordon, Danielle L Swaney, Nevan J Krogan, Gary R Whittaker, Luis Martinez-Sobrido, Hector C Aguilar, Melanie Ott
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013020
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