Dual-task-related gait patterns as possible marker of precocious and subclinical cognitive alterations in Parkinson disease
Abstract Subtle gait and cognitive dysfunction are common in Parkinson’s disease (PD), even before most evident clinical manifestations. Such alterations can be assumed as hypothetical phenotypical and prognostic/progression markers. To compare spatiotemporal gait parameters in PD patients with thre...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-85118-8 |
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| author | F. Di Filippo G. De Biasi M. Russo C. Ricciardi N. Pisani A. Volzone M. Aiello S. Cuoco M. Calabrese M. Romano P. Barone M. Amboni |
| author_facet | F. Di Filippo G. De Biasi M. Russo C. Ricciardi N. Pisani A. Volzone M. Aiello S. Cuoco M. Calabrese M. Romano P. Barone M. Amboni |
| author_sort | F. Di Filippo |
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| description | Abstract Subtle gait and cognitive dysfunction are common in Parkinson’s disease (PD), even before most evident clinical manifestations. Such alterations can be assumed as hypothetical phenotypical and prognostic/progression markers. To compare spatiotemporal gait parameters in PD patients with three cognitive status: cognitively intact (PD-noCI), with subjective cognitive impairment (PD-SCI) and with mild cognitive impairment (PD-MCI) in order to detect subclinical gait differences. One hundred PD patients were consecutively enrolled and divided in three groups based on both the first item od MDS-UPDRS part I and an extensive neuropsychological evaluation: 41 PD-noCI, 15 PD-SCI and 44 PD-MCI. They were evaluated with gait analysis acquired in three different conditions (normal gait, motor and cognitive dual task). Spatiotemporal variables were extracted. A univariate statistical analysis (parametric ANOVA test or non-parametric Kruskal–Wallis test, as appropriate) with post-hoc analysis was carried out in order to evaluate the significant differences among the groups. In normal gait task, the three groups showed several differences, all due to the comparison between PD-MCI and PD-noCI, as disclosed by post-hoc analysis. In dual task conditions, mostly in the cognitive dual task, the three groups showed increased gait alterations that, at post-hoc analysis, mirrored the magnitude of cognitive dysfunction (PD-noCI < PD-SCI < PD-MCI). Peculiar prodromal gait patterns—especially those highlighted by cognitive dual task—could be considered possible markers to objectify self-reported symptoms-based construct, like SCI, and to early intercept subjects with different clinical evolutions and prognoses, even representing an innovative clustering/phenotyping tool for PD subtypes. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-a50c933cae504b60b797e20b12c9e18d2025-02-02T12:20:01ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-85118-8Dual-task-related gait patterns as possible marker of precocious and subclinical cognitive alterations in Parkinson diseaseF. Di Filippo0G. De Biasi1M. Russo2C. Ricciardi3N. Pisani4A. Volzone5M. Aiello6S. Cuoco7M. Calabrese8M. Romano9P. Barone10M. Amboni11Department of Medicine, Surgery and Dentistry, Center for Neurodegenerative Diseases (CEMAND), University of SalernoDepartment of Medicine, Surgery and Dentistry, Center for Neurodegenerative Diseases (CEMAND), University of SalernoDepartment of Electrical Engineering and Information Technology, University of Naples “Federico II”Department of Electrical Engineering and Information Technology, University of Naples “Federico II”Department of Advanced Biomedical Sciences, University of Naples “Federico II”Department of Medicine, Surgery and Dentistry, Center for Neurodegenerative Diseases (CEMAND), University of SalernoScientific Institutes for Research, Hospitalization and Healthcare (IRCSS) SYNLAB SDNDepartment of Medicine, Surgery and Dentistry, Center for Neurodegenerative Diseases (CEMAND), University of SalernoDepartment of Medicine, Surgery and Dentistry, Center for Neurodegenerative Diseases (CEMAND), University of SalernoDepartment of Electrical Engineering and Information Technology, University of Naples “Federico II”Department of Medicine, Surgery and Dentistry, Center for Neurodegenerative Diseases (CEMAND), University of SalernoDepartment of Medicine, Surgery and Dentistry, Center for Neurodegenerative Diseases (CEMAND), University of SalernoAbstract Subtle gait and cognitive dysfunction are common in Parkinson’s disease (PD), even before most evident clinical manifestations. Such alterations can be assumed as hypothetical phenotypical and prognostic/progression markers. To compare spatiotemporal gait parameters in PD patients with three cognitive status: cognitively intact (PD-noCI), with subjective cognitive impairment (PD-SCI) and with mild cognitive impairment (PD-MCI) in order to detect subclinical gait differences. One hundred PD patients were consecutively enrolled and divided in three groups based on both the first item od MDS-UPDRS part I and an extensive neuropsychological evaluation: 41 PD-noCI, 15 PD-SCI and 44 PD-MCI. They were evaluated with gait analysis acquired in three different conditions (normal gait, motor and cognitive dual task). Spatiotemporal variables were extracted. A univariate statistical analysis (parametric ANOVA test or non-parametric Kruskal–Wallis test, as appropriate) with post-hoc analysis was carried out in order to evaluate the significant differences among the groups. In normal gait task, the three groups showed several differences, all due to the comparison between PD-MCI and PD-noCI, as disclosed by post-hoc analysis. In dual task conditions, mostly in the cognitive dual task, the three groups showed increased gait alterations that, at post-hoc analysis, mirrored the magnitude of cognitive dysfunction (PD-noCI < PD-SCI < PD-MCI). Peculiar prodromal gait patterns—especially those highlighted by cognitive dual task—could be considered possible markers to objectify self-reported symptoms-based construct, like SCI, and to early intercept subjects with different clinical evolutions and prognoses, even representing an innovative clustering/phenotyping tool for PD subtypes.https://doi.org/10.1038/s41598-025-85118-8Gait analysisSpatio-temporal parametersKinematicsParkinson’s diseaseMild cognitive impairmentSubjective cognitive impairment |
| spellingShingle | F. Di Filippo G. De Biasi M. Russo C. Ricciardi N. Pisani A. Volzone M. Aiello S. Cuoco M. Calabrese M. Romano P. Barone M. Amboni Dual-task-related gait patterns as possible marker of precocious and subclinical cognitive alterations in Parkinson disease Scientific Reports Gait analysis Spatio-temporal parameters Kinematics Parkinson’s disease Mild cognitive impairment Subjective cognitive impairment |
| title | Dual-task-related gait patterns as possible marker of precocious and subclinical cognitive alterations in Parkinson disease |
| title_full | Dual-task-related gait patterns as possible marker of precocious and subclinical cognitive alterations in Parkinson disease |
| title_fullStr | Dual-task-related gait patterns as possible marker of precocious and subclinical cognitive alterations in Parkinson disease |
| title_full_unstemmed | Dual-task-related gait patterns as possible marker of precocious and subclinical cognitive alterations in Parkinson disease |
| title_short | Dual-task-related gait patterns as possible marker of precocious and subclinical cognitive alterations in Parkinson disease |
| title_sort | dual task related gait patterns as possible marker of precocious and subclinical cognitive alterations in parkinson disease |
| topic | Gait analysis Spatio-temporal parameters Kinematics Parkinson’s disease Mild cognitive impairment Subjective cognitive impairment |
| url | https://doi.org/10.1038/s41598-025-85118-8 |
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