Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG1 antibody
Subcutaneous injection is the preferred route of administration for many antibody therapeutics for reasons that include its speed and convenience. However, the small volume limit (typically [Formula: see text]2 mL) for subcutaneous delivery often necessitates antibody formulations at high concentrat...
Saved in:
Main Authors: | Jing Dai, Saeed Izadi, Jonathan Zarzar, Patrick Wu, Angela Oh, Paul J. Carter |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2024-12-01
|
Series: | mAbs |
Subjects: | |
Online Access: | https://www.tandfonline.com/doi/10.1080/19420862.2024.2304282 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Modulation of the high concentration viscosity of IgG1 antibodies using clinically validated Fc mutations
by: Joel Heisler, et al.
Published: (2024-12-01) -
Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies
by: Wen-Ting K. Tsai, et al.
Published: (2024-12-01) -
Evaluation the Efficacy of ELISA IgG, IgM and IgA Tests for Diagnosis of Helicobacter pylori
by: Hogir Mohammed Shukri Saadi, et al.
Published: (2018-09-01) -
Predicting the clinical subcutaneous absorption rate constant of monoclonal antibodies using only the primary sequence: a machine learning approach
by: Ronghua Bei, et al.
Published: (2024-12-01) -
RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties
by: Barnabas Nyesiga, et al.
Published: (2024-12-01)