Yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysis
In this study, the impacts of egg consumption on mice model of metabolic syndrome (MetS) were comparatively investigated. Mice were divided into five groups (n=8): normal diet group (ND), high-fat diet group (HFD), HFD with whole egg group (WE), HFD with free-yolk egg substitute group (YFES), and HF...
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Tsinghua University Press
2024-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023001593 |
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| author | Zhihui Yu Lingyu Fan Fei Tai Lixin Zhang Xiaoyu Zhang Yisheng Chen |
| author_facet | Zhihui Yu Lingyu Fan Fei Tai Lixin Zhang Xiaoyu Zhang Yisheng Chen |
| author_sort | Zhihui Yu |
| collection | DOAJ |
| description | In this study, the impacts of egg consumption on mice model of metabolic syndrome (MetS) were comparatively investigated. Mice were divided into five groups (n=8): normal diet group (ND), high-fat diet group (HFD), HFD with whole egg group (WE), HFD with free-yolk egg substitute group (YFES), and HFD with lovastatin group (Lov). Main biochemical indexes and a non-targeted lipidomic analysis were employed to insight the lipid profile changes in serum. It was revealed that WE could significantly improve serum biochemical indexes by reducing body weight, low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), while increasing high-density lipoprotein cholesterol. YFES exhibited remarkably better performance in increasing phosphatidylglycerol and phosphatidic acids, while decreasing phosphatidylinositol than WE. A total of 50 differential lipids biomarkers tightly related to glycerophospholipids metabolism were screened out. Carnitine C18:2 and C12:1, SM (d18:0/12:0), and SM (d18:1/14:1) were significantly upregulated in YFES compared to WE. YFES reduced expression of SREBP-1c and Cpt1a, while did not affect the expression of PPAR-α. Sphingomyelin biomarkers were positively related to the TC (|r| > 0.6), while PPAR-α was negatively correlated with triglyceride and LDL-C levels. To sum up, YFES attenuated HFD-induced MetS by improving the serum phospholipids, which account for its modulation of glycerophospholipid metabolism. |
| format | Article |
| id | doaj-art-a5078e2724f04504b834a988c1096dee |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-a5078e2724f04504b834a988c1096dee2025-02-03T05:54:06ZengTsinghua University PressFood Science and Human Wellness2213-45302024-01-01131482493Yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysisZhihui Yu0Lingyu Fan1Fei Tai2Lixin Zhang3Xiaoyu Zhang4Yisheng Chen5College of Food Science and Engineering, Shanxi Agricultural University, Taigu 030801, China; Insitute of Food Nutrition and Safety, Shanxi Agricultural University, Taiyuan 030031, ChinaCollege of Food Science and Engineering, Shanxi Agricultural University, Taigu 030801, ChinaCollege of Food Science and Engineering, Shanxi Agricultural University, Taigu 030801, ChinaCollege of Food Science and Engineering, Shanxi Agricultural University, Taigu 030801, ChinaCollege of Food Science and Engineering, Shanxi Agricultural University, Taigu 030801, ChinaCollege of Food Science and Engineering, Shanxi Agricultural University, Taigu 030801, China; Insitute of Food Nutrition and Safety, Shanxi Agricultural University, Taiyuan 030031, China; Shanxi Key Laboratory of Edible Fungi for Loess Plateau, Taigu 030801, China; Corresponding author at: College of Food Science and Engineering, Shanxi Agricultural University, Taigu 030801, China.In this study, the impacts of egg consumption on mice model of metabolic syndrome (MetS) were comparatively investigated. Mice were divided into five groups (n=8): normal diet group (ND), high-fat diet group (HFD), HFD with whole egg group (WE), HFD with free-yolk egg substitute group (YFES), and HFD with lovastatin group (Lov). Main biochemical indexes and a non-targeted lipidomic analysis were employed to insight the lipid profile changes in serum. It was revealed that WE could significantly improve serum biochemical indexes by reducing body weight, low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), while increasing high-density lipoprotein cholesterol. YFES exhibited remarkably better performance in increasing phosphatidylglycerol and phosphatidic acids, while decreasing phosphatidylinositol than WE. A total of 50 differential lipids biomarkers tightly related to glycerophospholipids metabolism were screened out. Carnitine C18:2 and C12:1, SM (d18:0/12:0), and SM (d18:1/14:1) were significantly upregulated in YFES compared to WE. YFES reduced expression of SREBP-1c and Cpt1a, while did not affect the expression of PPAR-α. Sphingomyelin biomarkers were positively related to the TC (|r| > 0.6), while PPAR-α was negatively correlated with triglyceride and LDL-C levels. To sum up, YFES attenuated HFD-induced MetS by improving the serum phospholipids, which account for its modulation of glycerophospholipid metabolism.http://www.sciencedirect.com/science/article/pii/S2213453023001593Metabolic syndromeWhole eggYolk free egg substituteSerumLipidomics |
| spellingShingle | Zhihui Yu Lingyu Fan Fei Tai Lixin Zhang Xiaoyu Zhang Yisheng Chen Yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysis Food Science and Human Wellness Metabolic syndrome Whole egg Yolk free egg substitute Serum Lipidomics |
| title | Yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysis |
| title_full | Yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysis |
| title_fullStr | Yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysis |
| title_full_unstemmed | Yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysis |
| title_short | Yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysis |
| title_sort | yolk free egg substitute improves the serum phospholipid profile of mice with metabolic syndrome based on lipidomic analysis |
| topic | Metabolic syndrome Whole egg Yolk free egg substitute Serum Lipidomics |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023001593 |
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