Mosquito- and tick-borne orthoflaviviruses cross an in vitro endothelial-astrocyte barrier

IntroductionThe genus Orthoflavivirus of the Flaviviridae family includes several notable pathogens such as mosquito-borne West-Nile virus (Orthoflavivirus nilense, WNV) and Tick-borne encephalitis virus (Orthoflavivirus encephalitidis, TBEV) that are highly neurotropic and may cause severe neurolog...

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Main Authors:	Felix Schweitzer, Lara-Jasmin Schröder, Alina Friedrichs, Viktoria Gudi, Thomas Skripuletz, Imke Steffen, Martin Palus, Daniel Růžek, Albert Osterhaus, Chittappen Kandiyil Prajeeth
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Cellular and Infection Microbiology
Subjects:	orthoflavivirus blood-brain barrier endothelial cells astrocytes neuroinvasion transendothelial electrical resistance
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2025.1624636/full
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Mosquito- and tick-borne orthoflaviviruses cross an in vitro endothelial-astrocyte barrier

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