The intestinal mucosa-associated microbiota in IBD-associated arthritis displays lower relative abundance of Roseburia intestinalis
The most common extra-intestinal manifestation (EIM) of inflammatory bowel disease (IBD), IBD-associated arthritis (IAA), occurs in 25–40% of patients and can be debilitating. In IBD, mucosal and stool microbiota richness is decreased, and compositional changes can precede or accompany disease onset...
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2505114 |
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| author | Madeline Alizadeh Uni Wong Bernadette C. Siaton Michael T. France Seema A. Patil Lauren George Dania Hudhud Kiran Motwani William H. Scott Jean-Pierre Raufman Erik C. von Rosenvinge Raymond K. Cross Jacques Ravel |
| author_facet | Madeline Alizadeh Uni Wong Bernadette C. Siaton Michael T. France Seema A. Patil Lauren George Dania Hudhud Kiran Motwani William H. Scott Jean-Pierre Raufman Erik C. von Rosenvinge Raymond K. Cross Jacques Ravel |
| author_sort | Madeline Alizadeh |
| collection | DOAJ |
| description | The most common extra-intestinal manifestation (EIM) of inflammatory bowel disease (IBD), IBD-associated arthritis (IAA), occurs in 25–40% of patients and can be debilitating. In IBD, mucosal and stool microbiota richness is decreased, and compositional changes can precede or accompany disease onset. Likewise, spondyloarthritides are associated with altered gut microbiota, with overlapping bacterial signatures observed in IBD, suggesting key shared microbial factors are involved in both conditions. Much has been learned about the role of the intestinal microbiome in IBD, but less is known regarding its role in IAA. To address this knowledge gap, we analyzed the mucosa-associated intestinal microbiota of participants enrolled in the LOCATION-IBD cohort. Microbiota composition was established using 16S rRNA gene amplicon sequencing of intestinal biopsy samples taken from participants with IBD, with or without arthropathy. Microbiota samples clustered predominantly by participant, and similar taxa were present across the colon. The mucosal intestinal microbiota of females with IAA displayed a lower relative abundance of R. intestinalis, while males with IAA had a higher relative abundance of Corynebacterium, even when controlling for IBD-type, whether samples were taken from a site of inflammation and intestinal location. These findings indicate the mucosa-associated intestinal microbiota is associated with IAA in a sex-specific manner. |
| format | Article |
| id | doaj-art-a4d62719ee204acba480062a1bcd9232 |
| institution | OA Journals |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-a4d62719ee204acba480062a1bcd92322025-08-20T01:51:35ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2505114The intestinal mucosa-associated microbiota in IBD-associated arthritis displays lower relative abundance of Roseburia intestinalisMadeline Alizadeh0Uni Wong1Bernadette C. Siaton2Michael T. France3Seema A. Patil4Lauren George5Dania Hudhud6Kiran Motwani7William H. Scott8Jean-Pierre Raufman9Erik C. von Rosenvinge10Raymond K. Cross11Jacques Ravel12Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USADivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USADepartment of Veterans Affairs, Veterans Affairs Maryland Health Care System, Baltimore, MD, USAInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USADivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USADivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USADivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USADivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USADepartment of Veterans Affairs, Veterans Affairs Maryland Health Care System, Baltimore, MD, USADivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USADivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USADivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USAInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USAThe most common extra-intestinal manifestation (EIM) of inflammatory bowel disease (IBD), IBD-associated arthritis (IAA), occurs in 25–40% of patients and can be debilitating. In IBD, mucosal and stool microbiota richness is decreased, and compositional changes can precede or accompany disease onset. Likewise, spondyloarthritides are associated with altered gut microbiota, with overlapping bacterial signatures observed in IBD, suggesting key shared microbial factors are involved in both conditions. Much has been learned about the role of the intestinal microbiome in IBD, but less is known regarding its role in IAA. To address this knowledge gap, we analyzed the mucosa-associated intestinal microbiota of participants enrolled in the LOCATION-IBD cohort. Microbiota composition was established using 16S rRNA gene amplicon sequencing of intestinal biopsy samples taken from participants with IBD, with or without arthropathy. Microbiota samples clustered predominantly by participant, and similar taxa were present across the colon. The mucosal intestinal microbiota of females with IAA displayed a lower relative abundance of R. intestinalis, while males with IAA had a higher relative abundance of Corynebacterium, even when controlling for IBD-type, whether samples were taken from a site of inflammation and intestinal location. These findings indicate the mucosa-associated intestinal microbiota is associated with IAA in a sex-specific manner.https://www.tandfonline.com/doi/10.1080/19490976.2025.2505114Spondyloarthritismucosal gut microbiomeenteropathic arthritisCrohn’s diseaseulcerative colitisIBD-associated arthritis |
| spellingShingle | Madeline Alizadeh Uni Wong Bernadette C. Siaton Michael T. France Seema A. Patil Lauren George Dania Hudhud Kiran Motwani William H. Scott Jean-Pierre Raufman Erik C. von Rosenvinge Raymond K. Cross Jacques Ravel The intestinal mucosa-associated microbiota in IBD-associated arthritis displays lower relative abundance of Roseburia intestinalis Gut Microbes Spondyloarthritis mucosal gut microbiome enteropathic arthritis Crohn’s disease ulcerative colitis IBD-associated arthritis |
| title | The intestinal mucosa-associated microbiota in IBD-associated arthritis displays lower relative abundance of Roseburia intestinalis |
| title_full | The intestinal mucosa-associated microbiota in IBD-associated arthritis displays lower relative abundance of Roseburia intestinalis |
| title_fullStr | The intestinal mucosa-associated microbiota in IBD-associated arthritis displays lower relative abundance of Roseburia intestinalis |
| title_full_unstemmed | The intestinal mucosa-associated microbiota in IBD-associated arthritis displays lower relative abundance of Roseburia intestinalis |
| title_short | The intestinal mucosa-associated microbiota in IBD-associated arthritis displays lower relative abundance of Roseburia intestinalis |
| title_sort | intestinal mucosa associated microbiota in ibd associated arthritis displays lower relative abundance of roseburia intestinalis |
| topic | Spondyloarthritis mucosal gut microbiome enteropathic arthritis Crohn’s disease ulcerative colitis IBD-associated arthritis |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2025.2505114 |
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