Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain
Microglia are regarded as macrophages in the central nervous system (CNS) and play an important role in neuroinflammation in the CNS. Microglial activation has been strongly implicated in neurodegeneration in the brain. Increasing evidence also suggests an important role of spinal cord microglia in...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2013/753656 |
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| author | Sarah Taves Temugin Berta Gang Chen Ru-Rong Ji |
| author_facet | Sarah Taves Temugin Berta Gang Chen Ru-Rong Ji |
| author_sort | Sarah Taves |
| collection | DOAJ |
| description | Microglia are regarded as macrophages in the central nervous system (CNS) and play an important role in neuroinflammation in the CNS. Microglial activation has been strongly implicated in neurodegeneration in the brain. Increasing evidence also suggests an important role of spinal cord microglia in the genesis of persistent pain, by releasing the proinflammatory cytokines tumor necrosis factor-alpha (TNFα), Interleukine-1beta (IL-1β), and brain derived neurotrophic factor (BDNF). In this review, we discuss the recent findings illustrating the importance of microglial mediators in regulating synaptic plasticity of the excitatory and inhibitory pain circuits in the spinal cord, leading to enhanced pain states. Insights into microglial-neuronal interactions in the spinal cord dorsal horn will not only further our understanding of neural plasticity but may also lead to novel therapeutics for chronic pain management. |
| format | Article |
| id | doaj-art-a4ca4ff52a554030969c18f0d37e4c93 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-a4ca4ff52a554030969c18f0d37e4c932025-02-03T01:22:10ZengWileyNeural Plasticity2090-59041687-54432013-01-01201310.1155/2013/753656753656Microglia and Spinal Cord Synaptic Plasticity in Persistent PainSarah Taves0Temugin Berta1Gang Chen2Ru-Rong Ji3Pain Signaling and Plasticity Laboratory, Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, NC 27710, USAPain Signaling and Plasticity Laboratory, Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, NC 27710, USAPain Signaling and Plasticity Laboratory, Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, NC 27710, USAPain Signaling and Plasticity Laboratory, Departments of Anesthesiology and Neurobiology, Duke University Medical Center, Durham, NC 27710, USAMicroglia are regarded as macrophages in the central nervous system (CNS) and play an important role in neuroinflammation in the CNS. Microglial activation has been strongly implicated in neurodegeneration in the brain. Increasing evidence also suggests an important role of spinal cord microglia in the genesis of persistent pain, by releasing the proinflammatory cytokines tumor necrosis factor-alpha (TNFα), Interleukine-1beta (IL-1β), and brain derived neurotrophic factor (BDNF). In this review, we discuss the recent findings illustrating the importance of microglial mediators in regulating synaptic plasticity of the excitatory and inhibitory pain circuits in the spinal cord, leading to enhanced pain states. Insights into microglial-neuronal interactions in the spinal cord dorsal horn will not only further our understanding of neural plasticity but may also lead to novel therapeutics for chronic pain management.http://dx.doi.org/10.1155/2013/753656 |
| spellingShingle | Sarah Taves Temugin Berta Gang Chen Ru-Rong Ji Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain Neural Plasticity |
| title | Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain |
| title_full | Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain |
| title_fullStr | Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain |
| title_full_unstemmed | Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain |
| title_short | Microglia and Spinal Cord Synaptic Plasticity in Persistent Pain |
| title_sort | microglia and spinal cord synaptic plasticity in persistent pain |
| url | http://dx.doi.org/10.1155/2013/753656 |
| work_keys_str_mv | AT sarahtaves microgliaandspinalcordsynapticplasticityinpersistentpain AT temuginberta microgliaandspinalcordsynapticplasticityinpersistentpain AT gangchen microgliaandspinalcordsynapticplasticityinpersistentpain AT rurongji microgliaandspinalcordsynapticplasticityinpersistentpain |