A systematic review and functional in-silico analysis of genes and variants associated with amyotrophic lateral sclerosis

A systematic review and functional in-silico analysis of genes and variants associated with amyotrophic lateral sclerosis

IntroductionAmyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease characterized by the deterioration of upper and lower motor neurons. Affected patients experience progressive muscle weakness, including difficulty in swallowing and breathing; being respiratory failure...

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Main Authors: Carlos A. Arreola-Aldape, Jose A. Moran-Guerrero, Guillermo K. Pons-Monnier, Rogelio E. Flores-Salcido, Emmanuel Martinez-Ledesma, Luis M. Ruiz-Manriquez, K. Rebeca Razo-Alvarez, Daniela Mares-Custodio, Pablo J. Avalos-Montes, Jose A. Figueroa-Sanchez, Rocio Ortiz-Lopez, Hector R. Martínez, Raquel Cuevas-Diaz Duran
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Neuroscience
Subjects:
Amyotrophic Lateral Sclerosis
systematic review
genes
variants
mutations
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1598336/full
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