A genome-wide screen identifies genes required for erythroid differentiation

A genome-wide screen identifies genes required for erythroid differentiation

Abstract The complete array of genes required for terminal erythroid differentiation remains unknown. To address this knowledge gap, we perform a genome-scale CRISPR knock-out screen in the human erythroid progenitor cell line HUDEP-2 and validate candidate regulators of erythroid differentiation in...

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Main Authors: Greggory Myers, Ann Friedman, Lei Yu, Narges Pourmandi, Claire Kerpet, Masaki A. Ito, Rilie Saba, Vi Tang, Ayse Bilge Ozel, Ingrid L. Bergin, Craig N. Johnson, Chia-Jui Ku, Yu Wang, Ginette Balbin-Cuesta, Kim-Chew Lim, Zesen Lin, Claire Drysdale, Beth McGee, Ryo Kurita, Yukio Nakamura, Xiaofang Liu, David Siemieniak, Sharon A. Singh, Costas A. Lyssiotis, Ivan Maillard, Lois S. Weisman, James Douglas Engel, Rami Khoriaty
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58739-w
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