Coincidental Central Precocious Puberty and Wilms Tumor in a 5-Year-Old Girl
Wilms tumor is the most frequent pediatric renal malignancy, and its usual presentation is an abdominal mass or hematuria. Unusual presentations have also been reported, such as paraneoplastic syndromes (acquired von Willebrand disease, sudden death due to pulmonary embolism, and Cushing syndrome)....
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2019/5427207 |
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| author | Laura Kasongo Patricia Forget Ramona Corina Nicolescu |
| author_facet | Laura Kasongo Patricia Forget Ramona Corina Nicolescu |
| author_sort | Laura Kasongo |
| collection | DOAJ |
| description | Wilms tumor is the most frequent pediatric renal malignancy, and its usual presentation is an abdominal mass or hematuria. Unusual presentations have also been reported, such as paraneoplastic syndromes (acquired von Willebrand disease, sudden death due to pulmonary embolism, and Cushing syndrome). These conditions can precede, occur concomitantly, or present in a later phase of tumor development. Precocious puberty, as paraneoplastic endocrine syndrome, has already been described in children with malignant tumors (brain, gonadal, adrenal tumors, and hepatoblastoma). However, little is known about central precocious puberty, as paraneoplastic manifestation of nephroblastoma or secondary to its specific chemotherapy. Here, we report a case of Wilms tumor and simultaneous precocious puberty in a 5-year-old girl. The initial diagnosis was premature telarche, but the clinical and biological pubertal progression changed our diagnosis to idiopathic central precocious puberty. Chemotherapy and nephrectomy were well tolerated, and we began treatment with a gonadotropin-releasing hormone agonist which showed favorable outcomes over the short term. We highlight the need for early diagnosis and work-up in all patients of precocious puberty, in order to institute timely management. |
| format | Article |
| id | doaj-art-a4a8aad1b07b4e0ba34f2817c05615fe |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-a4a8aad1b07b4e0ba34f2817c05615fe2025-02-03T01:26:21ZengWileyCase Reports in Pediatrics2090-68032090-68112019-01-01201910.1155/2019/54272075427207Coincidental Central Precocious Puberty and Wilms Tumor in a 5-Year-Old GirlLaura Kasongo0Patricia Forget1Ramona Corina Nicolescu2Department of Pediatrics, University Hospital Liège, Boulevard du 12ème de Ligne nr 1, 4000 Liege, BelgiumDepartment of Pediatrics, University Hospital Liège, Boulevard du 12ème de Ligne nr 1, 4000 Liege, BelgiumPediatric Endocrinology Outpatient Clinic, Valdor Isosl Hospital, Rue Basse-Wez 145, 4020 Liège, BelgiumWilms tumor is the most frequent pediatric renal malignancy, and its usual presentation is an abdominal mass or hematuria. Unusual presentations have also been reported, such as paraneoplastic syndromes (acquired von Willebrand disease, sudden death due to pulmonary embolism, and Cushing syndrome). These conditions can precede, occur concomitantly, or present in a later phase of tumor development. Precocious puberty, as paraneoplastic endocrine syndrome, has already been described in children with malignant tumors (brain, gonadal, adrenal tumors, and hepatoblastoma). However, little is known about central precocious puberty, as paraneoplastic manifestation of nephroblastoma or secondary to its specific chemotherapy. Here, we report a case of Wilms tumor and simultaneous precocious puberty in a 5-year-old girl. The initial diagnosis was premature telarche, but the clinical and biological pubertal progression changed our diagnosis to idiopathic central precocious puberty. Chemotherapy and nephrectomy were well tolerated, and we began treatment with a gonadotropin-releasing hormone agonist which showed favorable outcomes over the short term. We highlight the need for early diagnosis and work-up in all patients of precocious puberty, in order to institute timely management.http://dx.doi.org/10.1155/2019/5427207 |
| spellingShingle | Laura Kasongo Patricia Forget Ramona Corina Nicolescu Coincidental Central Precocious Puberty and Wilms Tumor in a 5-Year-Old Girl Case Reports in Pediatrics |
| title | Coincidental Central Precocious Puberty and Wilms Tumor in a 5-Year-Old Girl |
| title_full | Coincidental Central Precocious Puberty and Wilms Tumor in a 5-Year-Old Girl |
| title_fullStr | Coincidental Central Precocious Puberty and Wilms Tumor in a 5-Year-Old Girl |
| title_full_unstemmed | Coincidental Central Precocious Puberty and Wilms Tumor in a 5-Year-Old Girl |
| title_short | Coincidental Central Precocious Puberty and Wilms Tumor in a 5-Year-Old Girl |
| title_sort | coincidental central precocious puberty and wilms tumor in a 5 year old girl |
| url | http://dx.doi.org/10.1155/2019/5427207 |
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