Celecoxib prevents malignant progression of smoking-induced lung tumors via suppression of the COX-2/PGE2 signaling pathway in mice

Celecoxib prevents malignant progression of smoking-induced lung tumors via suppression of the COX-2/PGE2 signaling pathway in mice

IntroductionLung cancer is characterized by a poor prognosis and is a significant comorbidity of chronic obstructive pulmonary disease (COPD). Therefore, effective chemopreventive agents are warranted. We evaluated the effects of the cyclooxygenase-2 (COX-2) inhibitor celecoxib on the prevention of...

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Main Authors: Kaori Sakurai, Shotaro Chubachi, Jun Miyata, Junko Hamamoto, Tatsuro Naganuma, Takashi Shimada, Shiro Otake, Shingo Nakayama, Hidehiro Irie, Akihiro Tsutsumi, Naofumi Kameyama, Ahmed E. Hegab, Masayuki Shimoda, Hideki Terai, Hiroyuki Yasuda, Yae Kanai, Makoto Arita, Koichi Fukunaga
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
chronic obstructive pulmonary disease
lung neoplasms
cyclooxygenase 2 inhibitor
smoking
prostaglandin E2
chemoprevention
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557790/full
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