Exploring the therapeutic mechanism of curcumin in spinal cord injury treatment based on network pharmacology, molecular dynamics simulation, and experimental validation

Exploring the therapeutic mechanism of curcumin in spinal cord injury treatment based on network pharmacology, molecular dynamics simulation, and experimental validation

IntroductionCurcumin, a natural active compound derived from plants, is widely used as a pigment across the globe. Research has demonstrated that curcumin possesses neuroprotective properties in spinal cord injuries (SCIs); however, its specific mechanisms of action remain unclear. This study aimed...

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Bibliographic Details
Main Authors: Yongzhi He, Jiachun Lu, Yushan Luo, Rizhao Pang, Xiaoming Hu, Lijuan Ding, Hua Xiao, Yunyun Wang, Wenchun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Chemistry
Subjects:
spinal cord injury
curcumin
natural products of plant origin
molecular mechanism
network pharmacology
molecular dynamics simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1568551/full
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