Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines
Pancreatic cancer has a very poor prognosis due to its high resistance to chemotherapeutic drugs, late diagnosis, and early metastasis, making it the most aggressive and lethal cancer. Hence, there is a pivotal need to find new effective preventive and curative treatments. In this study, extracted a...
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025006541 |
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| author | Reem A. Al Alawi Jörg D. Hoheisel Mohamed Saiel Saeed Alhamdani Younis Baqi |
| author_facet | Reem A. Al Alawi Jörg D. Hoheisel Mohamed Saiel Saeed Alhamdani Younis Baqi |
| author_sort | Reem A. Al Alawi |
| collection | DOAJ |
| description | Pancreatic cancer has a very poor prognosis due to its high resistance to chemotherapeutic drugs, late diagnosis, and early metastasis, making it the most aggressive and lethal cancer. Hence, there is a pivotal need to find new effective preventive and curative treatments. In this study, extracted and fractions obtained from date palm (Phoenix dactylifera L.) fruit using ethyl acetate and n-butanol as solvents. The prepared date fruit extracts and fractions were pharmacologically evaluated on three pancreatic cancer cell lines: PT45P1, PANC-1, and SUIT-2. Specific extracts demonstrated strong anti-proliferative activity. In particular Bu-IV was the most active n-butanol fraction tested at 500 μg/mL. Moreover, sub-fractions obtained from the ethyl acetate extract inhibited pancreatic cancer cell proliferation, especially fraction EA-III-2 tested at 50–150 μg/mL. These findings suggest that date fruit extracts contain nutraceuticals with potential therapeutic value in the treatment of pancreatic cancer. Future work will be focused on isolation and identification of the active compounds and explore their mechanisms of action. |
| format | Article |
| id | doaj-art-a48cc109684e4594b5bee1bc84bb2d74 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-a48cc109684e4594b5bee1bc84bb2d742025-01-30T05:14:42ZengElsevierHeliyon2405-84402025-02-01113e42274Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell linesReem A. Al Alawi0Jörg D. Hoheisel1Mohamed Saiel Saeed Alhamdani2Younis Baqi3Department of Chemistry, Faculty of Science, Sultan Qaboos University, P.O. Box 36, 123, Muscat, Sultanate of Oman; Division of Functional Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, GermanyDivision of Functional Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, GermanyDivision of Functional Genome Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, GermanyDepartment of Chemistry, Faculty of Science, Sultan Qaboos University, P.O. Box 36, 123, Muscat, Sultanate of Oman; Corresponding author.Pancreatic cancer has a very poor prognosis due to its high resistance to chemotherapeutic drugs, late diagnosis, and early metastasis, making it the most aggressive and lethal cancer. Hence, there is a pivotal need to find new effective preventive and curative treatments. In this study, extracted and fractions obtained from date palm (Phoenix dactylifera L.) fruit using ethyl acetate and n-butanol as solvents. The prepared date fruit extracts and fractions were pharmacologically evaluated on three pancreatic cancer cell lines: PT45P1, PANC-1, and SUIT-2. Specific extracts demonstrated strong anti-proliferative activity. In particular Bu-IV was the most active n-butanol fraction tested at 500 μg/mL. Moreover, sub-fractions obtained from the ethyl acetate extract inhibited pancreatic cancer cell proliferation, especially fraction EA-III-2 tested at 50–150 μg/mL. These findings suggest that date fruit extracts contain nutraceuticals with potential therapeutic value in the treatment of pancreatic cancer. Future work will be focused on isolation and identification of the active compounds and explore their mechanisms of action.http://www.sciencedirect.com/science/article/pii/S2405844025006541Date palm fruitMaceration extractionPancreatic cancerPhoenix dactylifera L.Proliferation |
| spellingShingle | Reem A. Al Alawi Jörg D. Hoheisel Mohamed Saiel Saeed Alhamdani Younis Baqi Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines Heliyon Date palm fruit Maceration extraction Pancreatic cancer Phoenix dactylifera L. Proliferation |
| title | Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines |
| title_full | Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines |
| title_fullStr | Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines |
| title_full_unstemmed | Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines |
| title_short | Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines |
| title_sort | phoenix dactylifera l date palm fruit extracts and fractions exhibit anti proliferative activity against human pancreatic cancer cell lines |
| topic | Date palm fruit Maceration extraction Pancreatic cancer Phoenix dactylifera L. Proliferation |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025006541 |
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