Pouchitis

Pouchitis is a major long-term complication of the continent ileostomy as well as the ileoanal pouch anastomosis. When diagnosed on the basis of clinical, endoscopic and histologic features, this syndrome has been demonstrated almost exclusively in patients with ulcerative colitis. The clinical cour...

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Main Author: W. R. Schouten
Format: Article
Language:English
Published: Wiley 1998-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1080/09629359891117
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author W. R. Schouten
author_facet W. R. Schouten
author_sort W. R. Schouten
collection DOAJ
description Pouchitis is a major long-term complication of the continent ileostomy as well as the ileoanal pouch anastomosis. When diagnosed on the basis of clinical, endoscopic and histologic features, this syndrome has been demonstrated almost exclusively in patients with ulcerative colitis. The clinical course, the endoscopic findings and the histologic abnormalities resemble those of ulcerative colitis. The association with extra-intestinal manifestations further supports the hypothesis that pouchitis represents ulcerative colitis in the small bowel. All ileal reservoirs show bacterial overgrowth, especially of anaerobes. As a response to this altered intraluminal environment chronic inflammation and incomplete colonic metaplasia occur. The efficiency of metronidazole does suggest that bacteriological factors play an important role in the pathogenesis of pouchitis.
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series Mediators of Inflammation
spelling doaj-art-a48bd6e640c040138ff79bfb3dcac20c2025-02-03T05:51:06ZengWileyMediators of Inflammation0962-93511466-18611998-01-017317518110.1080/09629359891117PouchitisW. R. Schouten0Department of Surgery, University Hospital Dijkzigt, Dr. Molewaterplein 40, Rotterdam 3015 GD, The NetherlandsPouchitis is a major long-term complication of the continent ileostomy as well as the ileoanal pouch anastomosis. When diagnosed on the basis of clinical, endoscopic and histologic features, this syndrome has been demonstrated almost exclusively in patients with ulcerative colitis. The clinical course, the endoscopic findings and the histologic abnormalities resemble those of ulcerative colitis. The association with extra-intestinal manifestations further supports the hypothesis that pouchitis represents ulcerative colitis in the small bowel. All ileal reservoirs show bacterial overgrowth, especially of anaerobes. As a response to this altered intraluminal environment chronic inflammation and incomplete colonic metaplasia occur. The efficiency of metronidazole does suggest that bacteriological factors play an important role in the pathogenesis of pouchitis.http://dx.doi.org/10.1080/09629359891117
spellingShingle W. R. Schouten
Pouchitis
Mediators of Inflammation
title Pouchitis
title_full Pouchitis
title_fullStr Pouchitis
title_full_unstemmed Pouchitis
title_short Pouchitis
title_sort pouchitis
url http://dx.doi.org/10.1080/09629359891117
work_keys_str_mv AT wrschouten pouchitis