Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation
Aim. To study the differences between acute presentation-autoimmune hepatitis (A-AIH) and chronic autoimmune hepatitis (C-AIH). Methods. Through long-term follow-up, 80 patients were included in our study by using the revised international autoimmune hepatitis group (IAIHG) score and were divided in...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/3513206 |
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| author | Yi Shen Changli Lu Ruoting Men Jianping Liu Tinghong Ye Li Yang |
| author_facet | Yi Shen Changli Lu Ruoting Men Jianping Liu Tinghong Ye Li Yang |
| author_sort | Yi Shen |
| collection | DOAJ |
| description | Aim. To study the differences between acute presentation-autoimmune hepatitis (A-AIH) and chronic autoimmune hepatitis (C-AIH). Methods. Through long-term follow-up, 80 patients were included in our study by using the revised international autoimmune hepatitis group (IAIHG) score and were divided into acute and chronic groups for comparison. Results. No significant difference was found in the gender, age, IAIHG score (pretreatment/posttreatment), definite diagnosis rate, extrahepatic autoimmune disease, onset time, or treatment before biopsy between the acute and chronic groups. In terms of clinical symptoms, A-AIH patients were more prone to jaundice, anorexia, yellow urine, and detesting oil than C-AIH patients, but melena only occurred in chronic group (P<0.05). The acute group exhibited more severe injury upon histological evaluation, with lobular inflammation and bile duct injury, especially central necrosis of the lobule, more pronounced in this group (P<0.05). Conclusion. A-AIH had manifestations of acute hepatitis and presented cholestasis. Serum indicators could preliminarily distinguish A-AIH and C-AIH. Histologically, the primary manifestation of A-AIH was lobular inflammation, which was usually accompanied by lobular central necrosis. For the diagnosis of A-AIH, more attention should be paid to long-term follow-up. This study was registered at ClinicalTrials.gov (identifier: NCT02994537). |
| format | Article |
| id | doaj-art-a48332f5aad64210acd592029f494fbd |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-a48332f5aad64210acd592029f494fbd2025-02-03T05:58:50ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972018-01-01201810.1155/2018/35132063513206Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute PresentationYi Shen0Changli Lu1Ruoting Men2Jianping Liu3Tinghong Ye4Li Yang5Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaAim. To study the differences between acute presentation-autoimmune hepatitis (A-AIH) and chronic autoimmune hepatitis (C-AIH). Methods. Through long-term follow-up, 80 patients were included in our study by using the revised international autoimmune hepatitis group (IAIHG) score and were divided into acute and chronic groups for comparison. Results. No significant difference was found in the gender, age, IAIHG score (pretreatment/posttreatment), definite diagnosis rate, extrahepatic autoimmune disease, onset time, or treatment before biopsy between the acute and chronic groups. In terms of clinical symptoms, A-AIH patients were more prone to jaundice, anorexia, yellow urine, and detesting oil than C-AIH patients, but melena only occurred in chronic group (P<0.05). The acute group exhibited more severe injury upon histological evaluation, with lobular inflammation and bile duct injury, especially central necrosis of the lobule, more pronounced in this group (P<0.05). Conclusion. A-AIH had manifestations of acute hepatitis and presented cholestasis. Serum indicators could preliminarily distinguish A-AIH and C-AIH. Histologically, the primary manifestation of A-AIH was lobular inflammation, which was usually accompanied by lobular central necrosis. For the diagnosis of A-AIH, more attention should be paid to long-term follow-up. This study was registered at ClinicalTrials.gov (identifier: NCT02994537).http://dx.doi.org/10.1155/2018/3513206 |
| spellingShingle | Yi Shen Changli Lu Ruoting Men Jianping Liu Tinghong Ye Li Yang Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation Canadian Journal of Gastroenterology and Hepatology |
| title | Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation |
| title_full | Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation |
| title_fullStr | Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation |
| title_full_unstemmed | Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation |
| title_short | Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation |
| title_sort | clinical and pathological characteristics of autoimmune hepatitis with acute presentation |
| url | http://dx.doi.org/10.1155/2018/3513206 |
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