Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering
Poly(3-hydroxybutyrate) is a natural polymer, produced by different bacteria, with good biocompatibility and biodegradability. Cardiovascular patches, scaffolds in tissue engineering and drug carriers are some of the possible biomedical applications of poly(3-hydroxybutyrate). In the past decade, ma...
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| Format: | Article |
| Language: | English |
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Sciendo
2020-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2020-0007 |
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| author | Dariš Barbara Knez Željko |
| author_facet | Dariš Barbara Knez Željko |
| author_sort | Dariš Barbara |
| collection | DOAJ |
| description | Poly(3-hydroxybutyrate) is a natural polymer, produced by different bacteria, with good biocompatibility and biodegradability. Cardiovascular patches, scaffolds in tissue engineering and drug carriers are some of the possible biomedical applications of poly(3-hydroxybutyrate). In the past decade, many researchers examined the different physico-chemical modifications of poly(3-hydroxybutyrate) in order to improve its properties for use in the field of bone tissue engineering. Poly(3-hydroxybutyrate) composites with hydroxyapatite and bioglass are intensively tested with animal and human osteoblasts in vitro to provide information about their biocompatibility, biodegradability and osteoinductivity. Good bone regeneration was proven when poly(3-hydroxy-butyrate) patches were implanted in vivo in bone tissue of cats, minipigs and rats. This review summarizes the recent reports of in vitro and in vivo studies of pure poly(3-hydroxy-butyrate) and poly(3-hydroxybutyrate) composites with the emphasis on their bioactivity and biocompatibility with bone cells. |
| format | Article |
| id | doaj-art-a4814f40133946d1849f7dccfb499b2a |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-a4814f40133946d1849f7dccfb499b2a2025-02-03T06:59:07ZengSciendoActa Pharmaceutica1846-95582020-03-0170111510.2478/acph-2020-0007acph-2020-0007Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineeringDariš Barbara0Knez Željko1University of Maribor, Faculty of Medicine, Institute of Biomedical Sciences, Maribor, SloveniaUniversity of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory for Separation Processes, Maribor, SloveniaPoly(3-hydroxybutyrate) is a natural polymer, produced by different bacteria, with good biocompatibility and biodegradability. Cardiovascular patches, scaffolds in tissue engineering and drug carriers are some of the possible biomedical applications of poly(3-hydroxybutyrate). In the past decade, many researchers examined the different physico-chemical modifications of poly(3-hydroxybutyrate) in order to improve its properties for use in the field of bone tissue engineering. Poly(3-hydroxybutyrate) composites with hydroxyapatite and bioglass are intensively tested with animal and human osteoblasts in vitro to provide information about their biocompatibility, biodegradability and osteoinductivity. Good bone regeneration was proven when poly(3-hydroxy-butyrate) patches were implanted in vivo in bone tissue of cats, minipigs and rats. This review summarizes the recent reports of in vitro and in vivo studies of pure poly(3-hydroxy-butyrate) and poly(3-hydroxybutyrate) composites with the emphasis on their bioactivity and biocompatibility with bone cells.https://doi.org/10.2478/acph-2020-0007poly(3-hydroxybutyrate)biopolymersbone tissue engineeringosteoblasts |
| spellingShingle | Dariš Barbara Knez Željko Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering Acta Pharmaceutica poly(3-hydroxybutyrate) biopolymers bone tissue engineering osteoblasts |
| title | Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering |
| title_full | Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering |
| title_fullStr | Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering |
| title_full_unstemmed | Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering |
| title_short | Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering |
| title_sort | poly 3 hydroxybutyrate promising biomaterial for bone tissue engineering |
| topic | poly(3-hydroxybutyrate) biopolymers bone tissue engineering osteoblasts |
| url | https://doi.org/10.2478/acph-2020-0007 |
| work_keys_str_mv | AT darisbarbara poly3hydroxybutyratepromisingbiomaterialforbonetissueengineering AT knezzeljko poly3hydroxybutyratepromisingbiomaterialforbonetissueengineering |