Analysis of periodontal status in Polish patients with rheumatoid arthritis treated with biological therapies
Introduction Periodontitis, characterized by inflammation affecting the tooth-supporting tissues, may increase the risk of rheumatoid arthritis (RA) or cardiovascular diseases. The aim of the study was to evaluate the periodontal status in RA patients and its impact on the inflammatory markers and r...
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| Language: | English |
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Termedia Publishing House
2024-11-01
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| Series: | Rheumatology |
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| Online Access: | https://reu.termedia.pl/Analysis-of-periodontal-status-in-Polish-patients-with-rheumatoid-arthritis-treated,194593,0,2.html |
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| author | Joanna Samborska-Mazur Dorota Sikorska Marzena Liliana Wyganowska |
| author_facet | Joanna Samborska-Mazur Dorota Sikorska Marzena Liliana Wyganowska |
| author_sort | Joanna Samborska-Mazur |
| collection | DOAJ |
| description | Introduction
Periodontitis, characterized by inflammation affecting the tooth-supporting tissues, may increase the risk of rheumatoid arthritis (RA) or cardiovascular diseases. The aim of the study was to evaluate the periodontal status in RA patients and its impact on the inflammatory markers and red cell parameters obtained from complete blood laboratory tests to study the risk of cardiovascular disease development.
Material and methods
The cross-sectional study included 50 patients with RA treated with biological therapies: tumor necrosis factor inhibitors, interleukin-6 blockers. Rheumatoid arthritis disease activity was assessed with Disease Activity Score with 28-joint count (DAS28). The periodontal indices modified Approximal Periodontal Index, modified Papillary Bleeding Index, and Periodontal Screening Index (PSI) were used to assess patients’ periodontal status. Serum levels of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were used as inflammatory markers and a potential cardiovascular risk factor.
Results
No statistically significant correlation was found between the periodontal status and RA activity. However, a statistically significant correlation was found between the CRP results and the PSI scores ( R = –0.264510, p = 0.048837). Evaluation of the red cell parameters showed statistically significant differences in the markers of inflammation ESR ( R = 0.369398, p = 0.008289) and CRP ( R = 0.367405, p = 0.008672). Red cell distribution width values were also correlated with RA activity ( R = 0.286387, p = 0.043769) and duration of the disease ( R = 0.339425, p = 0.015889).
Conclusions
A satisfactory periodontal status was found in most of the study group. Increased CRP levels in patients with periodontitis may indicate the negative impact of periodontal status on the general clinical condition of the patient. |
| format | Article |
| id | doaj-art-a475240412a8499c8c9792d79ee2bcde |
| institution | Kabale University |
| issn | 0034-6233 2084-9834 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Rheumatology |
| spelling | doaj-art-a475240412a8499c8c9792d79ee2bcde2025-01-27T11:20:37ZengTermedia Publishing HouseRheumatology0034-62332084-98342024-11-0162535135910.5114/reum/194593194593Analysis of periodontal status in Polish patients with rheumatoid arthritis treated with biological therapiesJoanna Samborska-Mazur0Dorota Sikorska1https://orcid.org/0000-0001-7326-6916Marzena Liliana Wyganowska2Private Dental Practice Joanna Samborska, Poznan, PolandDepartment of Rheumatology, Rehabilitation and Internal Medicine, Poznan University of Medical Sciences, PolandChair and Department of Dental Surgery, Periodontology, and Oral Mucosa Diseases, Poznan University of Medical Sciences, PolandIntroduction Periodontitis, characterized by inflammation affecting the tooth-supporting tissues, may increase the risk of rheumatoid arthritis (RA) or cardiovascular diseases. The aim of the study was to evaluate the periodontal status in RA patients and its impact on the inflammatory markers and red cell parameters obtained from complete blood laboratory tests to study the risk of cardiovascular disease development. Material and methods The cross-sectional study included 50 patients with RA treated with biological therapies: tumor necrosis factor inhibitors, interleukin-6 blockers. Rheumatoid arthritis disease activity was assessed with Disease Activity Score with 28-joint count (DAS28). The periodontal indices modified Approximal Periodontal Index, modified Papillary Bleeding Index, and Periodontal Screening Index (PSI) were used to assess patients’ periodontal status. Serum levels of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were used as inflammatory markers and a potential cardiovascular risk factor. Results No statistically significant correlation was found between the periodontal status and RA activity. However, a statistically significant correlation was found between the CRP results and the PSI scores ( R = –0.264510, p = 0.048837). Evaluation of the red cell parameters showed statistically significant differences in the markers of inflammation ESR ( R = 0.369398, p = 0.008289) and CRP ( R = 0.367405, p = 0.008672). Red cell distribution width values were also correlated with RA activity ( R = 0.286387, p = 0.043769) and duration of the disease ( R = 0.339425, p = 0.015889). Conclusions A satisfactory periodontal status was found in most of the study group. Increased CRP levels in patients with periodontitis may indicate the negative impact of periodontal status on the general clinical condition of the patient.https://reu.termedia.pl/Analysis-of-periodontal-status-in-Polish-patients-with-rheumatoid-arthritis-treated,194593,0,2.htmlperiodontitisrheumatic diseaseinflammation markers |
| spellingShingle | Joanna Samborska-Mazur Dorota Sikorska Marzena Liliana Wyganowska Analysis of periodontal status in Polish patients with rheumatoid arthritis treated with biological therapies Rheumatology periodontitis rheumatic disease inflammation markers |
| title | Analysis of periodontal status in Polish patients with rheumatoid arthritis treated with biological therapies |
| title_full | Analysis of periodontal status in Polish patients with rheumatoid arthritis treated with biological therapies |
| title_fullStr | Analysis of periodontal status in Polish patients with rheumatoid arthritis treated with biological therapies |
| title_full_unstemmed | Analysis of periodontal status in Polish patients with rheumatoid arthritis treated with biological therapies |
| title_short | Analysis of periodontal status in Polish patients with rheumatoid arthritis treated with biological therapies |
| title_sort | analysis of periodontal status in polish patients with rheumatoid arthritis treated with biological therapies |
| topic | periodontitis rheumatic disease inflammation markers |
| url | https://reu.termedia.pl/Analysis-of-periodontal-status-in-Polish-patients-with-rheumatoid-arthritis-treated,194593,0,2.html |
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