Age‐related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk
Abstract Aim Heart failure (HF) incidence increases markedly with age. We examined age‐associated longitudinal change in cardiac structure and function, and their prediction by age and cardiovascular disease (CVD) risk factors, in a community‐based cohort aged ≥60 years at increased CVD risk but wit...
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| Format: | Article |
| Language: | English |
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Wiley
2020-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.12687 |
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| author | Fei Fei Gong Jennifer M. Coller Michele McGrady Umberto Boffa Louise Shiel Danny Liew Simon Stewart Alice J. Owen Henry Krum Christopher M. Reid David L. Prior Duncan J. Campbell |
| author_facet | Fei Fei Gong Jennifer M. Coller Michele McGrady Umberto Boffa Louise Shiel Danny Liew Simon Stewart Alice J. Owen Henry Krum Christopher M. Reid David L. Prior Duncan J. Campbell |
| author_sort | Fei Fei Gong |
| collection | DOAJ |
| description | Abstract Aim Heart failure (HF) incidence increases markedly with age. We examined age‐associated longitudinal change in cardiac structure and function, and their prediction by age and cardiovascular disease (CVD) risk factors, in a community‐based cohort aged ≥60 years at increased CVD risk but without HF. Methods and results CVD risk factors were recorded in 3065 participants who underwent a baseline echocardiographic examination, of whom 2358 attended a follow‐up examination 3.8 [median, inter‐quartile range (IQR) 3.5, 4.2] years later. Median age was 71 (IQR 67, 76) years and 55% of participants were male. Age was associated with longitudinal increase in left ventricular (LV) mass index (LVMI); decrease in LV volumes; increase in LV ejection fraction; decrease in mitral annular systolic velocity; decrease in diastolic function (decreased mitral early diastolic annular velocity (e′); and increase in left atrial volume index, mitral peak early diastolic flow velocity (E)/e′ ratio, and tricuspid regurgitant velocity (TRVmax) in men and women, except for TRVmax in men). In multivariable analysis, longitudinal increase in LVMI was explained by CVD risk factors alone, whereas age, together with CVD risk factors, independently predicted longitudinal change in all other echocardiographic parameters. CVD risk factors were differentially associated with longitudinal change in different echocardiographic parameters. Conclusions Whereas the increase in LVMI with age was explained by CVD risk factors alone, age, together with risk factors, independently predicted longitudinal change in all other echocardiographic parameters, providing evidence for age‐specific mechanisms of change in cardiac structure and function as people age. Age‐associated change in LVMI, LV volumes, and diastolic function resembled what might be expected for the evolution of HF with preserved ejection fraction. Given the differential association of different CVD risk factors with longitudinal change in different echocardiographic parameters, therapies aimed at attenuation of age‐associated change in cardiac structure and function, and HF evolution, will likely need to address multiple CVD risk factors. |
| format | Article |
| id | doaj-art-a473bf2bf7c348fea9a58ccc4d97dc75 |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-a473bf2bf7c348fea9a58ccc4d97dc752025-02-03T10:25:47ZengWileyESC Heart Failure2055-58222020-06-01731344136110.1002/ehf2.12687Age‐related longitudinal change in cardiac structure and function in adults at increased cardiovascular riskFei Fei Gong0Jennifer M. Coller1Michele McGrady2Umberto Boffa3Louise Shiel4Danny Liew5Simon Stewart6Alice J. Owen7Henry Krum8Christopher M. Reid9David L. Prior10Duncan J. Campbell11St. Vincent's Institute of Medical Research Fitzroy Victoria AustraliaSt. Vincent's Hospital Melbourne Victoria AustraliaRoyal Prince Alfred Hospital Sydney New South Wales AustraliaSchool of Medicine University of Adelaide Adelaide South Australia AustraliaSchool of Public Health and Preventive Medicine Monash University Prahran Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Prahran Victoria AustraliaTorrens University Australia Adelaide South Australia AustraliaSchool of Public Health and Preventive Medicine Monash University Prahran Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Prahran Victoria AustraliaSchool of Public Health and Preventive Medicine Monash University Prahran Victoria AustraliaUniversity of Melbourne Parkville Victoria AustraliaSt. Vincent's Institute of Medical Research Fitzroy Victoria AustraliaAbstract Aim Heart failure (HF) incidence increases markedly with age. We examined age‐associated longitudinal change in cardiac structure and function, and their prediction by age and cardiovascular disease (CVD) risk factors, in a community‐based cohort aged ≥60 years at increased CVD risk but without HF. Methods and results CVD risk factors were recorded in 3065 participants who underwent a baseline echocardiographic examination, of whom 2358 attended a follow‐up examination 3.8 [median, inter‐quartile range (IQR) 3.5, 4.2] years later. Median age was 71 (IQR 67, 76) years and 55% of participants were male. Age was associated with longitudinal increase in left ventricular (LV) mass index (LVMI); decrease in LV volumes; increase in LV ejection fraction; decrease in mitral annular systolic velocity; decrease in diastolic function (decreased mitral early diastolic annular velocity (e′); and increase in left atrial volume index, mitral peak early diastolic flow velocity (E)/e′ ratio, and tricuspid regurgitant velocity (TRVmax) in men and women, except for TRVmax in men). In multivariable analysis, longitudinal increase in LVMI was explained by CVD risk factors alone, whereas age, together with CVD risk factors, independently predicted longitudinal change in all other echocardiographic parameters. CVD risk factors were differentially associated with longitudinal change in different echocardiographic parameters. Conclusions Whereas the increase in LVMI with age was explained by CVD risk factors alone, age, together with risk factors, independently predicted longitudinal change in all other echocardiographic parameters, providing evidence for age‐specific mechanisms of change in cardiac structure and function as people age. Age‐associated change in LVMI, LV volumes, and diastolic function resembled what might be expected for the evolution of HF with preserved ejection fraction. Given the differential association of different CVD risk factors with longitudinal change in different echocardiographic parameters, therapies aimed at attenuation of age‐associated change in cardiac structure and function, and HF evolution, will likely need to address multiple CVD risk factors.https://doi.org/10.1002/ehf2.12687Heart failureAgingRisk factorsEchocardiography |
| spellingShingle | Fei Fei Gong Jennifer M. Coller Michele McGrady Umberto Boffa Louise Shiel Danny Liew Simon Stewart Alice J. Owen Henry Krum Christopher M. Reid David L. Prior Duncan J. Campbell Age‐related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk ESC Heart Failure Heart failure Aging Risk factors Echocardiography |
| title | Age‐related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| title_full | Age‐related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| title_fullStr | Age‐related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| title_full_unstemmed | Age‐related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| title_short | Age‐related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| title_sort | age related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk |
| topic | Heart failure Aging Risk factors Echocardiography |
| url | https://doi.org/10.1002/ehf2.12687 |
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