Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells
Despite active research in virotherapy, this apparently safe modality has not achieved widespread success. The immune response to viral infection appears to be an essential factor that determines the efficacy of oncolytic viral therapy. The challenge is determining whether the viral-elicited immune...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2012/702839 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554031902359552 |
|---|---|
| author | Christopher A. Alvarez-Breckenridge Jianhua Yu Balveen Kaur Michael A. Caligiuri E. Antonio Chiocca |
| author_facet | Christopher A. Alvarez-Breckenridge Jianhua Yu Balveen Kaur Michael A. Caligiuri E. Antonio Chiocca |
| author_sort | Christopher A. Alvarez-Breckenridge |
| collection | DOAJ |
| description | Despite active research in virotherapy, this apparently safe modality has not achieved widespread success. The immune response to viral infection appears to be an essential factor that determines the efficacy of oncolytic viral therapy. The challenge is determining whether the viral-elicited immune response is a hindrance or a tool for viral treatment. NK cells are a key component of innate immunity that mediates antiviral immunity while also coordinating tumor clearance. Various reports have suggested that the NK response to oncolytic viral therapy is a critical factor in premature viral clearance while also mediating downstream antitumor immunity. As a result, particular attention should be given to the NK cell response to various oncolytic viral vectors and how their antiviral properties can be suppressed while maintaining tumor clearance. In this review we discuss the current literature on the NK response to oncolytic viral infection and how future studies clarify this intricate response. |
| format | Article |
| id | doaj-art-a46798d848c34531afb29672768aa4f2 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-a46798d848c34531afb29672768aa4f22025-02-03T05:52:39ZengWileyAdvances in Virology1687-86391687-86472012-01-01201210.1155/2012/702839702839Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer CellsChristopher A. Alvarez-Breckenridge0Jianhua Yu1Balveen Kaur2Michael A. Caligiuri3E. Antonio Chiocca4Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, USAThe Ohio State University Comprehensive Cancer Center, The Ohio State University, Wiseman Hall, 400 West 12th Avenue, Columbus, OH 43210, USADardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USAThe Ohio State University Comprehensive Cancer Center, The Ohio State University, Wiseman Hall, 400 West 12th Avenue, Columbus, OH 43210, USADardinger Laboratory for Neuro-Oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USADespite active research in virotherapy, this apparently safe modality has not achieved widespread success. The immune response to viral infection appears to be an essential factor that determines the efficacy of oncolytic viral therapy. The challenge is determining whether the viral-elicited immune response is a hindrance or a tool for viral treatment. NK cells are a key component of innate immunity that mediates antiviral immunity while also coordinating tumor clearance. Various reports have suggested that the NK response to oncolytic viral therapy is a critical factor in premature viral clearance while also mediating downstream antitumor immunity. As a result, particular attention should be given to the NK cell response to various oncolytic viral vectors and how their antiviral properties can be suppressed while maintaining tumor clearance. In this review we discuss the current literature on the NK response to oncolytic viral infection and how future studies clarify this intricate response.http://dx.doi.org/10.1155/2012/702839 |
| spellingShingle | Christopher A. Alvarez-Breckenridge Jianhua Yu Balveen Kaur Michael A. Caligiuri E. Antonio Chiocca Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells Advances in Virology |
| title | Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells |
| title_full | Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells |
| title_fullStr | Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells |
| title_full_unstemmed | Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells |
| title_short | Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells |
| title_sort | deciphering the multifaceted relationship between oncolytic viruses and natural killer cells |
| url | http://dx.doi.org/10.1155/2012/702839 |
| work_keys_str_mv | AT christopheraalvarezbreckenridge decipheringthemultifacetedrelationshipbetweenoncolyticvirusesandnaturalkillercells AT jianhuayu decipheringthemultifacetedrelationshipbetweenoncolyticvirusesandnaturalkillercells AT balveenkaur decipheringthemultifacetedrelationshipbetweenoncolyticvirusesandnaturalkillercells AT michaelacaligiuri decipheringthemultifacetedrelationshipbetweenoncolyticvirusesandnaturalkillercells AT eantoniochiocca decipheringthemultifacetedrelationshipbetweenoncolyticvirusesandnaturalkillercells |