Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg
Sepsis-induced myocardial injury has become a major threat to patient health and safety. Intestinal microbiota imbalance plays a crucial role in sepsis regulation. Using 16srRNA technology, we explored how intestinal colonization of Clostridium butyricum over 28 days impacted mice with LPS-induced s...
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Elsevier
2025-01-01
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| Series: | Immunobiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171298524000755 |
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| author | Jinglin Zhao Liuli Wu Rupan Zhang Mei Yuan Junchao Huang Xiongfei Jia Xiaoqin Mao |
| author_facet | Jinglin Zhao Liuli Wu Rupan Zhang Mei Yuan Junchao Huang Xiongfei Jia Xiaoqin Mao |
| author_sort | Jinglin Zhao |
| collection | DOAJ |
| description | Sepsis-induced myocardial injury has become a major threat to patient health and safety. Intestinal microbiota imbalance plays a crucial role in sepsis regulation. Using 16srRNA technology, we explored how intestinal colonization of Clostridium butyricum over 28 days impacted mice with LPS-induced sepsis. Significant changes were noted in the gut microbiota of the mice, highlighting that C. butyricum can positively influence the immune state in septic myocardial injury models. The bacterium's ability to prevent intestinal mucosal damage and alleviate the immunosuppressive state during the later stages of sepsis by regulating CD4 + CD25 + FOXP3 + Treg cells is particularly noteworthy. This suggests a therapeutic role for C. butyricum in sepsis management by protecting against myocardial injury and improving immune regulation. |
| format | Article |
| id | doaj-art-a45c2a64cafd40748f28583977afd5d0 |
| institution | Kabale University |
| issn | 0171-2985 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Immunobiology |
| spelling | doaj-art-a45c2a64cafd40748f28583977afd5d02025-01-27T04:21:41ZengElsevierImmunobiology0171-29852025-01-012301152857Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + TregJinglin Zhao0Liuli Wu1Rupan Zhang2Mei Yuan3Junchao Huang4Xiongfei Jia5Xiaoqin Mao6Department of Medical Laboratory, Kunming Children's Hospital, Children's Hospital Affiliated to Kunming Medical University, Kunming 650000, Yunnan Province, ChinaThe Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming 650500, ChinaYan'an Hospital of Kunming City, Kunming 650000, Yunnan Province, ChinaDepartment of Medical Laboratory, Kunming Children's Hospital, Children's Hospital Affiliated to Kunming Medical University, Kunming 650000, Yunnan Province, ChinaThe First People's Hospital of Yunnan Province New Kun Hua Hospital, Kunming 650000, Yunnan Province, ChinaDepartment of Clinical laboratory，920th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Kunming 650000, Yunnan Province, China; Corresponding authors at: The First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming 650032, Yunnan, China.The Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming 650500, China; Corresponding authors at: The First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming 650032, Yunnan, China.Sepsis-induced myocardial injury has become a major threat to patient health and safety. Intestinal microbiota imbalance plays a crucial role in sepsis regulation. Using 16srRNA technology, we explored how intestinal colonization of Clostridium butyricum over 28 days impacted mice with LPS-induced sepsis. Significant changes were noted in the gut microbiota of the mice, highlighting that C. butyricum can positively influence the immune state in septic myocardial injury models. The bacterium's ability to prevent intestinal mucosal damage and alleviate the immunosuppressive state during the later stages of sepsis by regulating CD4 + CD25 + FOXP3 + Treg cells is particularly noteworthy. This suggests a therapeutic role for C. butyricum in sepsis management by protecting against myocardial injury and improving immune regulation.http://www.sciencedirect.com/science/article/pii/S0171298524000755SepsisMyocardial injuryClostridium butyricumRegulatory T-cells |
| spellingShingle | Jinglin Zhao Liuli Wu Rupan Zhang Mei Yuan Junchao Huang Xiongfei Jia Xiaoqin Mao Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg Immunobiology Sepsis Myocardial injury Clostridium butyricum Regulatory T-cells |
| title | Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg |
| title_full | Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg |
| title_fullStr | Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg |
| title_full_unstemmed | Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg |
| title_short | Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg |
| title_sort | clostridium butyricum attenuates lps induced myocardial injury in septic mice by modulating cd4 cd25 foxp3 treg |
| topic | Sepsis Myocardial injury Clostridium butyricum Regulatory T-cells |
| url | http://www.sciencedirect.com/science/article/pii/S0171298524000755 |
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